HIV therapeutic possibilities of gold compounds
HIV therapeutic possibilities of gold compounds
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DOI：
10.1007/s10534-010-9293-5
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发表时间：
2010-04-01
期刊：
影响因子：
3.5
通讯作者：
Meyer, Debra
中科院分区：
文献类型：
--
作者：
Fonteh, Pascaline N.;Keter, Frankline K.;Meyer, Debra
高效抗逆转录病毒疗法（HAART）已导致由人类免疫缺陷病毒（HIV）引起的获得性免疫缺陷综合征的死亡率和发病率降低。HAART的耐药性和毒性导致了对HIV感染的新型抑制剂的研究。基于金的化合物已经显示出对广泛的临床病症和微生物感染（包括HIV-1）的有希望的活性。一个典型的例子是金诺芬，它导致正在治疗银屑病关节炎的HIV患者的CD 4 + T细胞计数升高。此外，存在关于逆转录酶（RT）、蛋白酶（PR）和病毒进入宿主细胞的基于金的抑制剂的报道。这些和其他特点的金为基础的艾滋病毒药物在这里进行审查。
Highly active antiretroviral therapy (HAART) has resulted in decreased mortality and morbidity from the acquired immune deficiency syndrome caused by the human immunodeficiency virus (HIV). Drug resistance and toxicity of HAART has led to the search for novel inhibitors of HIV infection. Gold-based compounds have shown promising activity against a wide range of clinical conditions and microorganism infections including HIV-1. A typical example is auranofin which resulted in an elevated CD4+ T-cell count in an HIV patient being treated for psoriatic arthritis. In addition, reports exist on gold-based inhibitors of reverse transcriptase (RT), protease (PR) and viral entry of host cells. These and other characteristics of gold-based HIV drugs are reviewed here.