Sequestered fulvinol-related polyacetylenes in Peltodoris atromaculata.
Sequestered fulvinol-related polyacetylenes in Peltodoris atromaculata.
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DOI：
10.1021/np500298h
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发表时间：
2014-06
影响因子：
5.1
通讯作者：
M. Ciavatta;Genoveffa Nuzzo;Kentaro Takada;V. Mathieu;R. Kiss;G. Villani;M. Gavagnin
中科院分区：
文献类型：
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作者：
M. Ciavatta;Genoveffa Nuzzo;Kentaro Takada;V. Mathieu;R. Kiss;G. Villani;M. Gavagnin
地中海海蛞蝓Peltodoris atromaculata，已被收集，而喂养Haliclona fulva被证明螯合长链富乙烯醇样聚乙炔代谢产物（化合物2-5）的猎物。它们是沿着先前报道的从软体动物和海绵的乙醚提取物中分离出的溴肾素。通过核磁共振谱和串联快原子轰击质谱分析确定了它们的结构。化合物5对SKMEL-28黑色素瘤细胞系表现出体外生长抑制作用。
The Mediterranean dorid nudibranch Peltodoris atromaculata that had been collected while feeding on Haliclona fulva was shown to sequester long-chain fulvinol-like polyacetylene metabolites (compounds 2-5) from the prey. They were isolated along with previously reported bromorenierins from the diethyl ether extracts of both the mollusk and the sponge. Their structures were elucidated by NMR spectroscopy and tandem FABMS analysis. Compound 5 exhibited in vitro growth inhibitory effects against the SKMEL-28 melanoma cell line.