Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase.
Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase.
复制标题
过度表达超氧化物歧化酶的小鼠鞘内暴露于裂解血后血红素加氧酶的诱导减弱。
DOI：
10.1016/s0304-3940(02)01233-8
复制
发表时间：
2003
影响因子：
2.5
通讯作者：
Noble,LindaJ
中科院分区：
文献类型：
--
作者：
Weinzierl,Martin;Mautes,AE;Lin,Yong;Noble,LindaJ
Induction of heme oxygenase-1 (HO-1) in the spinal cord was studied in adult wildtype and transgenic mice overexpressing the antioxidant copper, zinc superoxide dismutase (CuZn SOD) 24 h after intrathecal infusion of heterologous lysed blood. Double immunolabeling techniques were used to determine the extent to which HO-1 was induced in astrocytes and microglia/macrophages. HO-1 was induced in both astrocytes and microglia/macrophages in the dorsal horns near the site of infusion of lysed blood in all mice. However, the number of HO-1 labeled cells was significantly less in the transgenic as compared to the wildtype animals. Together, these findings suggest that lysed blood preferentially induces HO-1 in glia and macrophages through the generation of oxidative stress.
