Cancer stem cells and strategies for targeted drug delivery.
Cancer stem cells and strategies for targeted drug delivery.
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DOI：
10.1007/s13346-020-00863-9
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发表时间：
2021-10
影响因子：
5.4
通讯作者：
Panyam J
中科院分区：
文献类型：
--
作者：
Cao J;Bhatnagar S;Wang J;Qi X;Prabha S;Panyam J
肿瘤干细胞(CSCs)是一小部分具有高致瘤活性、自我更新能力和多向分化潜能的癌细胞。包括常规化疗、放射治疗和分子靶向治疗在内的标准抗肿瘤疗法对CSCs无效，往往会导致CSCs的浓缩，从而导致肿瘤复发。因此，假设靶向CSCs是提高癌症治疗效果的关键。本文就肿瘤干细胞标志物及其在肿瘤生长、侵袭、转移和耐药中的作用以及肿瘤干细胞微环境等方面的研究进展作一综述。此外，还研究了CSC靶向策略，包括使用靶向药物输送系统。
Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis and drug resistance as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.
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