Saposin D: a sphingomyelinase activator.
Saposin D: a sphingomyelinase activator.
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Saposin D：鞘磷脂酶激活剂。
DOI：
10.1016/s0006-291x(88)80855-6
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发表时间：
1988
影响因子：
3.1
通讯作者：
O'Brien,JS
中科院分区：
文献类型：
--
作者：
Morimoto,S;Martin,BM;Kishimoto,Y;O'Brien,JS
Saposin D是一种新发现的热稳定的10 kDa糖蛋白，从Gaucher脾中分离并纯化至均一。从其氨基末端的化学测序表明其氨基酸序列和saposin前体蛋白saposin的第四个结构域的推导的氨基酸序列之间的共线性。鞘脂激活蛋白D特异性地刺激酸性鞘磷脂酶，但对测试的其他水解酶没有显著影响。
Saposin D, a newly discovered heat-stable, 10 kDa glycoprotein, was isolated from Gaucher spleen and purified to homogeneity. Chemical sequencing from its amino terminus demonstrated colinearity between its amino acid sequence and the deduced amino acid sequence of the fourth domain of prosaposin, the precursor of saposin proteins. Saposin D specifically stimulates acid sphingomyelinase but has no significant effect on the other hydrolases tested.