Skin grafts in nude mice. 3. Fate of grafts from man and donors of other taxonomic classes.
Skin grafts in nude mice. 3. Fate of grafts from man and donors of other taxonomic classes.
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裸鼠皮肤移植。
DOI：
10.1111/j.1699-0463.1974.tb03831.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
J. Rygaard
中科院分区：
文献类型：
--
作者：
J. Rygaard
鸟类、爬行动物和正常人类的皮肤移植被小鼠很好地接受，正如本研究和其他研究所证明的那样。组织学研究显示移植物的良好结合，脾脏和淋巴结的变化与动物其他移植后观察到的相似。研究的共识表明，在目前正在研究的实验动物中，小鼠是各种来源的移植物的抵抗力最低的受体，无论是制备的还是非制备的。这是人体免疫缺陷程度的表现。1970年calnein提出的一个有趣的问题可以得到回答。虽然它的“内部环境”可能被认为与鸟类和爬行动物有很大的不同，但老鼠是鸟类和爬行动物组织的适当宿主。
Avian, reptilian and normal human skin grafts are well accepted by thenudemouse, as demonstrated by this and other studies. Histological studies show consistently good incorporation of grafts, and changes in spleen and lymph nodes similar to those observed after other transplants in the animal. The consensus of studies evidence that thenudemouse is the least resistant recipient of grafts of diverse origin among the experimental animals, prepared or otherwise, which are under study today. This is an expression of the extent of the immunological deficiency in thenude.An interesting question asked byCalnein 1970 can be answered. Though its ‘milieu interieur’ could be thought to be widely different from the avian and the reptilian, thenudemouse is an adequate host of avian and reptilian tissue.