N-Myc induces the tumor progression of prostate cancer by regulating FSCN1
N-Myc induces the tumor progression of prostate cancer by regulating FSCN1
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DOI：
10.3892/or.2020.7775
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发表时间：
2020-11-01
期刊：
影响因子：
4.2
通讯作者：
Yin, Yu
中科院分区：
文献类型：
--
作者：
He, Guifang;Li, Mingfeng;Yin, Yu
癌蛋白N-Myc在多种类型的癌症中具有致癌作用，在前列腺癌(Pca)中可引起去势抵抗，并通过调节多个靶基因而导致小细胞神经内分泌癌的发生。免疫组织化学染色、RT-qPCR、Western blotting、创面愈合和CCK-8检测N-Myc、FSCN1、AR和CgA在人和细胞水平的表达。免疫组织化学结果显示，N-Myc原癌基因蛋白(N-Myc)和FSCN1蛋白在PCa组织中的表达明显高于增生性组织(P
The oncoprotein N-Myc has a carcinogenic effect in numerous types of cancer, and it can cause castration resistance in prostate cancer (PCa), and leads to the development of small cell neuroendocrine cancer by regulating multiple target genes. Immunohistochemical staining, RT-qPCR, western blotting, wound healing and CCK-8 assays were used to detect the expression of N-Myc and FSCN1 as well as AR and CgA at the human level and cell level. The immunohistochemical results revealed that the protein levels of N-Myc proto-oncogene protein (N-Myc) and fascin (FSCN1) in PCa were significantly higher than that of hyperplastic tissues (P