Effect of ageing on hypoxic exercise cardiorespiratory, muscle and cerebral oxygenation responses in healthy humans
Effect of ageing on hypoxic exercise cardiorespiratory, muscle and cerebral oxygenation responses in healthy humans
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衰老对健康人低氧运动心肺、肌肉和大脑氧合反应的影响
DOI：
10.1113/ep085949
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发表时间：
2017
影响因子：
2.7
通讯作者：
S. Vergès
中科院分区：
文献类型：
--
作者：
L. Puthon;P. Bouzat;P. Robach;A. Favre;S. Doutreleau;S. Vergès
这项研究的中心问题是什么？本研究旨在确定在最大增量运动中，衰老对心肺和组织氧合反应的影响。主要发现是什么及其重要性？年龄较大的健康受试者在休息和适度运动时保持低氧心肺和组织氧合反应。在最大运动时，他们的缺氧通气反应减少，但与年轻人相比，最大功率输出减少相似。这项研究表明，在适度运动之前，低氧反应一直保持到70岁，因此衰老不是高海拔居住的禁忌症。
What is the central question of this study? This study aimed to determine the effect of ageing on cardiorespiratory and tissue oxygenation responses to hypoxia during maximal incremental exercise. What is the main finding and its importance? Older healthy subjects had preserved hypoxic cardiorespiratory and tissue oxygenation responses at rest and during moderate exercise. At maximal exercise, they had a reduced hypoxic ventilatory response but similar maximal power output reduction compared with young individuals. This study suggests that until moderate exercise, hypoxic responses are preserved until the age of 70 years and therefore that ageing is not a contraindication for high‐altitude sojourn.