Antimicrobial agents of 4-methoxysalicylaldehyde isolated from Periploca sepium oil against foodborne bacteria: structure–activity relationship
Antimicrobial agents of 4-methoxysalicylaldehyde isolated from Periploca sepium oil against foodborne bacteria: structure–activity relationship
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DOI：
10.1007/s13765-018-0373-5
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发表时间：
2018-05
影响因子：
3.2
通讯作者：
E. Jeong;Myung-Ji Lee;Min Kang;Hoi-Seon Lee
中科院分区：
文献类型：
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作者：
E. Jeong;Myung-Ji Lee;Min Kang;Hoi-Seon Lee
本研究旨在评估从杠柳中分离出的 4-甲氧基水杨醛及其衍生物对六种食源性细菌（单增李斯特菌、鼠伤寒沙门氏菌、福氏志贺氏菌、宋内氏菌、中间葡萄球菌和金黄色葡萄球菌）的抗菌活性。从 P. 中提取的精油。乌贼根对食源性细菌具有很强的抗菌活性。 P的抗菌化合物。通过色谱技术分离的sepium被鉴定为4-甲氧基水杨醛。为了比较4-甲氧基水杨醛及其衍生物（4-羟基水杨醛、水杨醛、3-甲氧基水杨醛、5-甲氧基水杨醛、3-甲基水杨醛和5-甲基水杨醛）的抗菌活性，进行了MIC测试。 4-甲氧基水杨醛 (MIC 30.1–67.3 µg/mL)、4-羟基水杨醛 (MIC 41.1–61.5 µg/mL) 和 4-甲氧基水杨醛 (MIC 41.3–92.1 µg/mL) 对所有测试微生物均表现出这些活性。结果表明，4-甲氧基水杨醛及其衍生物代表了天然抗菌替代品。
This study was designed to evaluate the antimicrobial activities of 4-methoxysalicylaldehyde isolated fromPeriploca sepiumand its derivatives against six foodborne bacteria (Listeria monocytogenes,Salmonella typhimurium,Shigella flexneri,S. sonnei,Staphylococcus intermediusandS. aureus). Essential oil extracted fromP. sepiumroots exhibits strong antimicrobial activity against foodborne bacteria. The antimicrobial compound ofP. sepiumisolated by chromatographic techniques was identified as 4-methoxysalicylaldehyde. To compare the antimicrobial activities of 4-methoxysalicylaldehyde and its derivatives (4-hydroxysalicylaldehyde, salicylaldehyde, 3-methoxysalicylaldehyde, 5-methoxysalicylaldehyde, 3-methylsalicylaldehyde, and 5-methylsalicylaldehyde), the MIC test was performed. These activities were exhibited by 4-methoxysalicylaldehyde (MIC 30.1–67.3 μg/mL) followed by 4-hydroxysalicylaldehyde (MIC 41.1–61.5 μg/mL) and 4-methoxysalicylaldehyde (MIC 41.3–92.1 μg/mL) against all tested microorganisms. The results indicate that 4-methoxysalicylaldehyde and its derivatives represent natural antimicrobial alternatives.