Variability in the size of individual airways over the course of one year.
Variability in the size of individual airways over the course of one year.
复制标题
一年内各个气道大小的变化。
DOI：
10.1164/ajrccm.151.4.7697246
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Mitzner,W
中科院分区：
文献类型：
--
作者：
Brown,RH;Zerhouni,EA;Mitzner,W
几项研究已经检查了肺气道参数（如FEV 1和FVC）标准临床测量值随时间推移的重现性。这些研究表明，在数月和数年的时间内，这种测量具有相当一致的可重复性。尽管这种传统的肺功能测试可以提供肺功能的定量测量，但是它们不能提供对个体气道的局部或区域变化的任何洞察。因此，在犬的纵向研究中，我们使用高分辨率计算机断层扫描（HRCT）在1年内多次直接测量同一犬气道的基线大小（横截面积）。我们比较了个体气道大小的变异性，包括受试者内和受试者间气道的不同大小和季节性差异。在15个月的时间内，对5只麻醉、插管和通气的犬进行了5 - 8次研究。在所有情况下，在FRC下，在呼气末对犬进行HRCT扫描。所有个体气道显示出随时间推移的相当大的尺寸变异性，如通过变异系数（CV）测量的（范围：9.2至69.3）。随着时间的推移，狗体内单个气道的大小变化多达两倍。一些狗的气道大小的总体变异性也显著大于其他狗（p < 0.01），但这种变异性与气道大小（p = 0.34）和季节无关。这些发现表明，在气道口径的实质性的局部和区域的变化，将无法检测到与传统的肺功能测试。（250字处删节）
Several studies have examined the reproducibility over time of standard clinical measurements of pulmonary airways parameters, such as FEV1 and FVC. These studies indicate fairly consistent reproducibility of such measurements over periods of months and years. Although such traditional pulmonary function tests can provide quantitative measures of lung function, they do not provide any insight into the local or regional variation of individual airways. Therefore, in a longitudinal study in dogs, we directly measured the baseline size (cross-sectional area) of the same individual canine airways multiple times over a 1-yr period, using high-resolution computed tomography (HRCT). We compared the variability of individual airway size both within and between subjects to the various sizes of airways and to seasonal differences in size. Five anesthetized, intubated, and ventilated dogs were studied between five and eight times over a 15-mo period. HRCT scans were acquired at end expiration with the dogs at FRC on all occasions. All individual airways showed considerable variability in size over time as measured by the coefficient of variation (CV) (range: 9.2 to 69.3). The sizes of individual airways within a dog were seen to change by as much as twofold over time. Some dogs also showed significantly greater overall variability in airway size than did other dogs (p < 0.01), but this variability was related neither to the size of the airway (p = 0.34) nor to the season. These findings indicate a substantial local and regional variability in airway caliber that would not be detectable with conventional pulmonary function tests.(ABSTRACT TRUNCATED AT 250 WORDS)