Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA
Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA
复制标题
Trim44 的新功能通过稳定 VISA 促进抗病毒反应
DOI：
10.4049/jimmunol.1202507
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发表时间：
2013-04-01
影响因子：
4.4
通讯作者：
Sun, Bing
中科院分区：
文献类型：
--
作者：
Yang, Bo;Wang, Jie;Sun, Bing
Virus-induced signaling adaptor (VISA) functions as a critical adaptor in the regulation of both the production of type I IFNs and the subsequent control of the innate antiviral response. In this study, we demonstrate that tripartite motif (Trim)44 interacts with VISA and promotes VISA-mediated antiviral responses. The overexpression of Trim44 enhances the cellular response to viral infection, whereas Trim44 knockdown yields the opposite effect. Trim44 stabilizes VISA by preventing VISA ubiquitination and degradation. These findings suggest that Trim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA.
