A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice.
A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian influenza virus in mice.
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基于杆状病毒双表达系统的疫苗可为小鼠提供针对 H9N2 禽流感病毒致命攻击的完全保护
DOI：
10.1186/1743-422x-8-273
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发表时间：
2011-06-04
期刊：
影响因子：
4.8
通讯作者：
Liao M
中科院分区：
文献类型：
--
作者：
Lin W;Fan H;Cheng X;Ye Y;Chen X;Ren T;Qi W;Liao M
研究背景H9 N2亚型禽流感病毒在禽类中高度流行。虽然这些病毒通常只引起轻度至中度疾病，但它们可以感染多种物种，包括鸡、鹌鹑、火鸡、鸭、鹅、野鸡、鹦鹉和鸽子，甚至传播给哺乳动物物种，包括人类，结果用BV-Dual-1免疫的小鼠模型诱导了更强的免疫应答，HA比那些接种了编码相同抗原的DNA疫苗的人。结论BV-Dual-HA可作为H9 N2病毒感染的候选疫苗。
BackgroundAvian influenza viruses of H9N2 subtype have become highly prevalent in avian species. Although these viruses generally cause only mild to moderate disease, they can infect a wide variety of species, including chickens, quail, turkeys, ducks, geese, pheasant, partridge, and pigeon, even transmitted to mammalian species, including humans, accelerating the efforts to devise protective strategies against them.ResultsThe results showed that stronger immune responses were induced in a mouse model immunized with BV-Dual-HA than in those vaccinated with a DNA vaccine encoding the same antigen. Moreover, complete protection against lethal challenge with H9N2 virus was observed in mice.ConclusionBV-Dual-HA could be utilized as a vaccine candidate against H9N2 virus infection.