C-TYPE NATRIURETIC PEPTIDE INHIBITS INTIMAL THICKENING AFTER VASCULAR INJURY
C-TYPE NATRIURETIC PEPTIDE INHIBITS INTIMAL THICKENING AFTER VASCULAR INJURY
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DOI：
10.1006/bbrc.1993.1616
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发表时间：
1993-05-28
影响因子：
3.1
通讯作者：
MATSUO, H
中科院分区：
文献类型：
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作者：
FURUYA, M;AISAKA, K;MATSUO, H
最近我们发现c型利钠肽（CNP）通过提高cGMP抑制培养大鼠血管平滑肌细胞的增殖。我们现在在体内测试了CNP是否能抑制大鼠颈总动脉风干损伤引起的内膜病变的发展。与对照大鼠相比，CNP （1 μg/kg/min，静脉滴注）治疗14天和5天，损伤后14天内膜横截面积分别减少70%和60%。我们还发现CNP能有效刺激颈动脉内膜增厚的cGMP产生，但在完整的颈动脉中没有。这些结果表明，CNP特异性受体/胍基环化酶GC-B在血管损伤部位表达，CNP可能有效预防冠状动脉成形术后内膜增厚引起的再狭窄。
Recently we have found that C-type natriuretic peptide (CNP) inhibits proliferation of cultured rat vascular smooth muscle cells through an elevation of cGMP. We have now tested whether administration of CNP inhibits the development of intimal lesions induced by air-drying injury in rat common carotid arteries in vivo. CNP treatment (1 μg/kg/min, i.v. infusion) for either 14 or 5 days resulted in 70% or 60% reduction, respectively, of intimal cross-section area 14 days after injury as compared with control rats. We also found that CNP potently stimulated cGMP production in injured carotid arteries with intimal thickening, but not in intact ones. These results indicate that GC-B, CNP specific receptor/guanylyl cyclase, is expressed at the sites of vascular injury, and that CNP might be efficacious in the prevention of restenosis caused by intimal thickening following coronary angioplasty.