Sympathetic transients caused by abrupt alterations of carotid baroreceptor activity in humans.
Sympathetic transients caused by abrupt alterations of carotid baroreceptor activity in humans.
复制标题
人类颈动脉压力感受器活性突然改变引起的交感神经瞬变。
DOI：
10.1152/ajpheart.1982.242.2.h185
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Eckberg,DL
中科院分区：
文献类型：
--
作者：
Wallin,BG;Eckberg,DL
我们研究了10名健康成人颈动脉压力感受器在交感神经流出到肌肉血管床和副交感神经流出到心脏的短期调制中的作用。传入颈动脉压力感受器的活动进行修改，30毫米汞柱的颈部吸力或压力施加在举行呼气，和传出交感神经活动进行了测量，微电极插入到腓神经肌束。交感神经反应的条件重要的颈动脉跨壁压的方向性变化：增加压力（颈部吸力或颈部压力的偏移）抑制（完全）交感神经活动，和减少压力（颈部吸力或颈部压力的偏移）增强交感神经活动。反应发生后的潜伏期约2秒，并没有持续只要颈室压力的变化。心脏间期延长颈动脉跨壁压增加和颈动脉跨壁压降低缩短，但与交感神经反应，心脏反应适应颈室压力变化过程中只有轻微的。我们的研究结果表明，在人类一个共同的压力感受器输入处理不同的中央迷走神经和交感神经网络。肌肉交感神经对传入压力感受器流量水平变化的反应是深刻的，但短暂的。它们似乎更多地受到动脉压变化的影响，而不是动脉压的绝对水平。
We examined the role of carotid baroreceptors in the short-term modulation of sympathetic outflow to the muscle vascular bed and parasympathetic outflow to the heart in 10 healthy adults. Afferent carotid baroreceptor activity was modified with 30-mmHg neck suction or pressure applied during held expiration, and efferent sympathetic activity was measured with microelectrodes inserted percutaneously into peroneal nerve muscle fascicles. Sympathetic responses were conditioned importantly by directional changes of carotid transmural pressure: increased pressure (onset of neck suction or offset of neck pressure) inhibited (totally) sympathetic activity, and reduced pressure (offset of neck suction or onset of neck pressure) augmented sympathetic activity. Responses occurred after a latency of about 2 s and did not persist as long as changes of neck-chamber pressure. Cardiac intervals were prolonged by increased carotid transmural pressures and shortened by decreased carotid transmural pressures, but, in contrast to sympathetic responses, cardiac responses adapted only slightly during neck-chamber pressure changes. Our results suggest that in the human a common baroreceptor input is processed differently in central vagal and sympathetic networks. Muscle sympathetic responses to changing levels of afferent baroreceptor traffic are profound but transitory. They appear to be conditioned more by changes of arterial pressure than by its absolute levels.