Reliability of grading lissamine green conjunctival staining.
Reliability of grading lissamine green conjunctival staining.
复制标题
丽丝胺绿结膜染色分级的可靠性。
DOI：
10.1097/01.ico.0000208814.94495.a6
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发表时间：
2006
期刊：
影响因子：
2.8
通讯作者：
Nichols,JasonJ
中科院分区：
文献类型：
--
作者：
Berntsen,DavidA;Mitchell,GLynn;Nichols,JasonJ
目的：评价利沙明绿结膜像分级标准的可靠性。方法：用数码滑灯摄像机记录288名配戴隐形眼镜者右眼滴入液体利萨明绿后20秒的视频片段。选择了单一的鼻部和颞部静止图像。一名蒙面阅读器两次使用牛津评分表对图像进行评分，而另一名蒙面阅读器只对每张图像进行了一次评分。采用κ统计量和95%可信区间(CI)对样本按年龄、性别、隐形眼镜类型和疾病严重程度进行分层，以确定总体的等级内和等级间的可靠性。结果：鼻部(κSimple=0.69，95%CI，0.63~0.75)和颞部(κSimple=0.73，95%CI，0.67~0.79)图像都具有显著的等级内可靠性。鼻部(κSimple=0.5 1，95%CI，0.44~0.5 8)和颞部(κSimple=0.5 1，95%CI，0.44~0.5 8)图像的分级间可靠性中等。年龄、性别和隐形眼镜类型不影响检查者内部或之间的可靠性。疾病严重程度可能会影响检查员内部的可靠性，因为在染色较明显的图像中，时间图像的分级可靠性显著降低。结论：李萨明绿染色的级别内和级别之间的可靠性似乎至少是实质性到中等的。由于结膜染色的范围可能会影响可靠性，当研究可能包括有明显染色的患者时，应该考虑这一点。
Purpose:To assess the reliability of a lissamine green grading scale for conjunctival images.Methods:A 20-second video clip of the right eye of 288 contact lens-wearing individuals was recorded using a digital slip-lamp camera after instilling liquid lissamine green. A single nasal and temporal still image were selected. A masked reader used the Oxford grading scale to grade the images on two occasions whereas a second masked reader graded each image on 1 occasion. κ statistics and 95% confidence intervals (CIs) were used to determine the within-and between-grader reliability overall and when the sample was stratified by age, sex, contact lens type, and disease severity.Results:There was substantial within-grader reliability for both the nasal (κ simple= 0.69, 95% CI, 0.63-0.75) and temporal (κ simple= 0.73, 95% CI, 0.67-0.79) images. There was moderate between-grader reliability for both the nasal (κ simple= 0.51, 95% CI, 0.44-0.58) and temporal (κ simple= 0.51, 95% CI, 0.44-0.58) images. Age, sex, and contact lens type did not affect within-or between-examiner reliability. There may have been an influence of disease severity on within-examiner reliability, because grading of the temporal images was significantly less reliable in the images with more significant staining.Conclusion:Within-and between-grader reliability of lissamine green staining seems to be at least substantial to moderate. Because the extent of conjunctival staining may influence reliability, this should be considered when studies may include patients with significant staining.