Amygdala - frontal connectivity during emotion regulation
Amygdala - frontal connectivity during emotion regulation
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DOI：
10.1093/scan/nsm029
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发表时间：
2007-12-01
影响因子：
4.2
通讯作者：
Phan, K. Luan
中科院分区：
文献类型：
--
作者：
Banks, Sarah J.;Eddy, Kamryn T.;Phan, K. Luan
成功地控制情感部分取决于通过使用认知策略（即，重新评价）。最近的研究表明，额叶皮质区参与杏仁核反应性的调制和有效的情绪调节的调解。然而，受试者内杏仁核和前额叶皮层之间的区域间连接的影响调节的背景下是未知的。在这里，使用功能磁共振成像数据的心理生理相互作用分析，我们表明，在特定区域的额叶皮层（背外侧，背内侧，前扣带，眶）的活动与杏仁核活动的协变，这种功能的连接是依赖于重新评价任务。此外，杏仁核与眶额皮层和背内侧前额叶皮层的耦合强度预测了重新评价后负面情绪衰减的程度。这些发现强调了在情绪调节过程中边缘-额叶回路功能连接的重要性。
Successful control of affect partly depends on the capacity to modulate negative emotional responses through the use of cognitive strategies (i.e., reappraisal). Recent studies suggest the involvement of frontal cortical regions in the modulation of amygdala reactivity and the mediation of effective emotion regulation. However, within-subject inter-regional connectivity between amygdala and prefrontal cortex in the context of affect regulation is unknown. Here, using psychophysiological interaction analyses of functional magnetic resonance imaging data, we show that activity in specific areas of the frontal cortex ( dorsolateral, dorsal medial, anterior cingulate, orbital) covaries with amygdala activity and that this functional connectivity is dependent on the reappraisal task. Moreover, strength of amygdala coupling with orbitofrontal cortex and dorsal medial prefrontal cortex predicts the extent of attenuation of negative affect following reappraisal. These findings highlight the importance of functional connectivity within limbic-frontal circuitry during emotion regulation.