Use of right orbitofrontal repetitive transcranial magnetic stimulation (rTMS) augmentation for treatment-refractory obsessive-compulsive disorder with comorbid major depressive disorder.
Use of right orbitofrontal repetitive transcranial magnetic stimulation (rTMS) augmentation for treatment-refractory obsessive-compulsive disorder with comorbid major depressive disorder.
复制标题
使用右眶额重复经颅磁刺激（rTMS）增强治疗合并重度抑郁症的难治性强迫症。
DOI：
10.1016/j.psychres.2022.114856
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发表时间：
2022
影响因子：
11.3
通讯作者：
Leuchter,AndrewF
中科院分区：
文献类型：
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作者：
Tadayonnejad,Reza;Wilson,AndrewC;Chu,StephanieAnne;Corlier,Juliana;Citrenbaum,Cole;Ngo,ThucDoanP;Hovhannisyan,Emmily;Ginder,NathanielD;Levitt,JenniferG;Wilke,ScottA;Krantz,David;Bari,AusafA;Leuchter,AndrewF
我们研究了右眶额皮质（OFC）重复经颅磁刺激（rTMS）在难治性强迫症（OCD）和共病重度抑郁症患者中的安全性和有效性。所有受试者（n= 26）接受左侧背外侧前额叶皮层的兴奋性刺激，随后接受双侧辅助运动区的抑制性刺激，共10次。在18例早期OCD反应差的患者中，在第10次治疗后，用OFC抑制刺激增强治疗。OFC刺激的增强耐受性良好，并且与进一步缓解强迫症和抑郁症症状相关，特别是在患有更严重疾病的个体中。
We examined the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) of the right orbitofrontal cortex (OFC) in patients with refractory obsessive-compulsive disorder (OCD) and comorbid Major Depressive Disorder. All participants (n= 26) received excitatory stimulation of the left dorsolateral prefrontal cortex followed by inhibitory stimulation of bilateral supplementary motor area for 10 sessions. In 18 patients with poor early OCD response, treatment was augmented with OFC inhibitory stimulation after the tenth treatment session. Augmentation with OFC stimulation was well-tolerated, and associated with further alleviation of both OCD and depression symptoms, particularly in individuals with more severe illnesses.