BIOLOGICAL CHARACTERISTICS OF BREAST-CANCER IN OBESITY
BIOLOGICAL CHARACTERISTICS OF BREAST-CANCER IN OBESITY
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DOI：
10.1620/tjem.120.351
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发表时间：
1976-01-01
影响因子：
2.2
通讯作者：
NAKAMURA, T
中科院分区：
文献类型：
--
作者：
ABE, R;KUMAGAI, N;NAKAMURA, T
研究了肥胖患者与非肥胖患者乳腺癌的生物学特性。将134例乳腺癌患者按身高、体重分为瘦、正常、肥胖3类。肥胖患者5年生存率为55.6%；在包括瘦和正常受试者在内的非肥胖患者中，这一比例为79.9%。对肥胖乳腺癌患者预后不良的原因进行了临床和组织学研究。肥胖患者原发肿瘤、局部淋巴结累及及临床分期均较晚，以黏液癌为主（46%），肿瘤边缘浸润性较强(. γ。类型为64%)，血管受累发生率高（73%），淋巴结转移发生率高（58%），核分级低。
Biological characteristics of breast cancer in obese patients were investigated in comparison with nonobese patients. Patients (134) with breast cancer were divided into 3 categories: thin, normal and obese based on height and weight. Five year survival rate was 55.6% in obese patients; it was 79.9% in nonobese patients including thin and normal subjects. A cause for unfavorable prognosis in obese patients with breast cancer was clinically and histologically investigated. In obese patients the primary tumor, regional lymph node involvement and clinical stage were relatively advanced, scirrhous carcinoma was predominant (46%), the tumor margin was more infiltrative (.gamma.-type 64%), the incidence of vascular involvement was high (73%), lymph node metastases were frequent (58%) and nuclear grade was low.