Active spot-scanning test with heavy ions at HIRFL-CSR
Active spot-scanning test with heavy ions at HIRFL-CSR
复制标题
HIRFL-CSR 重离子主动点扫描测试
DOI：
10.1088/1674-1137/36/8/018
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发表时间：
2012-08-01
影响因子：
3.6
通讯作者：
Xiao Guo-Qing
中科院分区：
文献类型：
--
作者：
Dai Zhong-Ying;Li Qiang;Xiao Guo-Qing
基于HIRFL-CSR的冷却储存环，研制了一种用于重离子治疗的有源点束流传输系统。该系统利用一对正交（水平和垂直）的偶极磁体在靶区内横向扫描，并利用同步加速器的激活能量逐层纵向扫描。HIRFL-CSR的独特技术，如通过主动能量变化和磁偏转的剂量成形，构成了一个有前途的三维适形甚至调强放射治疗的重离子。在本文中，验证的主动能量变化和可操纵的波束偏转的校准示出，作为基本的功能组件的主动点扫描系统。此外，基于使用可操纵笔形波束创建均匀照射场的能力，已经进行了放射生物学实验，如细胞存活测量，旨在比较主动和被动波束递送下的放射生物学效应。
An active spot beam delivery system for heavy ion therapy has been developed based on the Cooling Storage Ring at HIRFL-CSR, where the pencil carbon-ion beams were scanned within a target volume transversely by a pair of orthogonal (horizontal and vertical) dipole magnets to paint the slices of the target volume and longitudinally by active energy variation of the synchrotron slice by slice. The unique techniques such as dose shaping via active energy variation and magnetic deflection constitute a promising three-dimensional conformal even intensity-modulated radiotherapy with heavy ions at HIRFL-CSR. In this paper, the verification of active energy variation and the calibration of steerable beam deflection are shown, as the basic functionality components of the active spot-scanning system. Additionally, based on the capability of creating homogeneous irradiation fields with steerable pencil beams, a radiobiological experiment like cell survival measurement has been performed aiming at comparison of the radiobiological effects under active and passive beam deliveries.