Affective Brain-Computer Interfaces As Enabling Technology for Responsive Psychiatric Stimulation.
Affective Brain-Computer Interfaces As Enabling Technology for Responsive Psychiatric Stimulation.
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情感脑机接口作为响应性精神刺激的支持技术。
DOI：
10.1080/2326263x.2014.912885
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Moritz,ChetT
中科院分区：
文献类型：
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作者：
Widge,AlikS;Dougherty,DarinD;Moritz,ChetT
临床上迫切需要响应式神经刺激器，其感测患者的大脑活动并提供有针对性的电刺激以抑制不必要的症状。精神疾病尤其如此，症状可能在一天中波动。情感BCI，从神经活动中解码情感体验，是针对边缘回路的响应刺激器的候选控制信号。然而，目前的情感解码器还不能区分病理性和健康的情绪极端。不分青红皂白的刺激传递会降低生活质量，并可能是有害的。我们认为，克服这一限制的关键是具体解码意志，特别是病人的意图，体验情绪调节。这些情绪调节信号已经存在于前额叶皮层（PFC）中，并且可以通过相对简单的BCI算法来提取。我们描述了PFC控制的边缘脑刺激的动物模型的初步数据，并讨论了临床前测试和可能的翻译的下一步。
There is a pressing clinical need for responsive neurostimulators, which sense a patient’s brain activity and deliver targeted electrical stimulation to suppress unwanted symptoms. This is particularly true in psychiatric illness, where symptoms can fluctuate throughout the day. Affective BCIs, which decode emotional experience from neural activity, are a candidate control signal for responsive stimulators targeting the limbic circuit. Present affective decoders, however, cannot yet distinguish pathologic from healthy emotional extremes. Indiscriminate stimulus delivery would reduce quality of life and may be actively harmful. We argue that the key to overcoming this limitation is to specifically decode volition, in particular the patient’s intention to experience emotional regulation. Those emotion-regulation signals already exist in prefrontal cortex (PFC), and could be extracted with relatively simple BCI algorithms. We describe preliminary data from an animal model of PFC-controlled limbic brain stimulation and discuss next steps for pre-clinical testing and possible translation.