Sleep duration and sleep quality are associated differently with alterations of glucose homeostasis
Sleep duration and sleep quality are associated differently with alterations of glucose homeostasis
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DOI：
10.1111/j.1464-5491.2012.03711.x
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发表时间：
2012-09-01
影响因子：
3.5
通讯作者：
Witte, D. R.
中科院分区：
文献类型：
--
作者：
Byberg, S.;Hansen, A. -L. S.;Witte, D. R.
迪亚贝特。地中海医院。29，e354e360(2012)摘要目标研究表明，睡眠时间不足和睡眠质量差会增加血糖调节受损和糖尿病的风险。然而，与葡萄糖稳态的特定标记物之间的联系却解释得不太好。这项研究的目的是在一项基于健康人群的研究样本中，探索睡眠时间和睡眠质量与葡萄糖稳态和糖耐量状态标记物的可能联系。方法这项研究包括771名来自丹麦基于人群的横断面Health2008研究的参与者。睡眠时间和睡眠质量采用自我报告的方式进行测量。血糖稳态的标志物来自三点口服葡萄糖耐量试验，包括空腹血糖、2小时血糖、糖化血红蛋白、两项胰岛素敏感性指标(胰岛素敏感性指数0、120和胰岛素敏感性的稳态模型评估)、β细胞功能和糖耐量状态的稳态模型评估。用多元线性回归和Logistic回归分析睡眠时间和睡眠质量与血糖、动态平衡和耐力指标的关系。结果睡眠时间增加1h，糖化血红蛋白(HbA1c)降低0.3 mm o l/m ol(0.3%)，糖调节受损风险降低25%。此外，睡眠质量每增加1点，胰岛素敏感性指数0,120和胰岛素敏感性的稳态模型评估都增加了2%，而β细胞功能的稳态模型评估则下降了1%。结论在本研究中，睡眠时间较短主要与较晚的血糖稳态改变有关，而较差的睡眠质量主要与较早的血糖稳态改变有关。因此，养成健康的睡眠习惯可能有利于健康人群的葡萄糖代谢。
Diabet. Med. 29, e354e360 (2012) Abstract Aims Studies suggest that inadequate sleep duration and poor sleep quality increase the risk of impaired glucose regulation and diabetes. However, associations with specific markers of glucose homeostasis are less well explained. The objective of this study was to explore possible associations of sleep duration and sleep quality with markers of glucose homeostasis and glucose tolerance status in a healthy population-based study sample. Methods The study comprised 771 participants from the Danish, population-based cross-sectional Health2008 study. Sleep duration and sleep quality were measured by self-report. Markers of glucose homeostasis were derived from a 3-point oral glucose tolerance test and included fasting plasma glucose, 2-h plasma glucose, HbA1c, two measures of insulin sensitivity (the insulin sensitivity index0,120 and homeostasis model assessment of insulin sensitivity), the homeostasis model assessment of beta-cell function and glucose tolerance status. Associations of sleep duration and sleep quality with markers of glucose homeostasis and tolerance were analysed by multiple linear and logistic regression. Results A 1-h increment in sleep duration was associated with a 0.3 mmol/mol (0.3%) decrement in HbA1c and a 25% reduction in the risk of having impaired glucose regulation. Further, a 1-point increment in sleep quality was associated with a 2% increase in both the insulin sensitivity index0,120 and homeostasis model assessment of insulin sensitivity, as well as a 1% decrease in homeostasis model assessment of beta-cell function. Conclusions In the present study, shorter sleep duration was mainly associated with later alterations in glucose homeostasis, whereas poorer sleep quality was mainly associated with earlier alterations in glucose homeostasis. Thus, adopting healthy sleep habits may benefit glucose metabolism in healthy populations.