Metabolically healthy obesity reduces the risk of Alzheimer's disease in elders: a longitudinal study
Metabolically healthy obesity reduces the risk of Alzheimer's disease in elders: a longitudinal study
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代谢健康的肥胖可降低老年人患阿尔茨海默病的风险：一项纵向研究
DOI：
10.18632/aging.102496
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发表时间：
2019-12-15
期刊：
影响因子：
5.2
通讯作者：
Yu, Jin-Tai
中科院分区：
文献类型：
--
作者：
Ma, Ling-Zhi;Huang, Yu-Yuan;Yu, Jin-Tai
具有良好代谢特征的超重/肥胖个体亚组被称为代谢健康超重/肥胖(MHO)。几项研究表明，MHO患者患心血管疾病和全程死亡的风险不会增加。然而，MHO是否与老年人阿尔茨海默病(AD)的过度风险有关仍不清楚。为了探索MHO表型中AD的风险，以及MHO是否与AD的神经退行性生物标志物相关，我们使用成人治疗小组III(ATP-III)标准评估了来自阿尔茨海默病神经成像倡议(ADNI)队列的1199名纵向老年人的体重指数-代谢状态表型。与代谢正常体重(MHNW)受试者相比，MHO受试者患AD的风险显著降低(校正后HR=0.73，95%CI：0.54~0.97)。在多变量线性回归模型中，研究了MHO与脑脊液(CSF)生物标记物、脑Aβ负荷和皮质结构的横断面关联。MHO与脑脊液Aβ(β=0.746，P=0.015)、海马体积(β=0.181，P=0.011)、全脑体积(β=0.133，P=0.004)呈正相关。老年人的MHO表型降低了AD的风险，其作用可能是由Aβ驱动的。
A subgroup of overweight/obese individuals, who had favorable metabolic profiles, was termed as metabolically healthy overweight/obese (MHO). Several studies suggested that MHO individuals were not at increased risk of cardiovascular disease and all-course mortality. However, whether MHO is associated with excess risk of Alzheimer's disease (AD) in elders remains unclear. To explore the risk of AD among MHO phenotype and investigate whether MHO associates with neurodegenerative biomarkers of AD, we assessed body mass index-metabolic status phenotypes of 1199 longitudinal elders from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort using the Adult Treatment Panel-III (ATP- III) criteria. MHO subjects were at a significantly decreased risk for AD (adjusted HR=0.73, 95% CI: 0.54-0.97) compared with metabolically healthy normal weight (MHNW) subjects. In multivariable linear regression models, the cross-sectional associations of MHO with cerebrospinal fluid (CSF) biomarkers, brain A beta load, and cortical structure were explored. MHO was positively correlated with CSF-A beta (beta=0.746, P=0.015), hippocampal volume (beta=0.181, P=0.011), and whole brain volume (beta=0.133, P=0.004). The MHO phenotype of the elder conferred a decreased risk of AD and its role may be driven by A beta.