Synaptic Vesicle Endocytosis
Synaptic Vesicle Endocytosis
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DOI：
10.1101/cshperspect.a005645
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发表时间：
2012-09-01
影响因子：
7.2
通讯作者：
De Camilli, Pietro
中科院分区：
文献类型：
--
作者：
Saheki, Yasunori;De Camilli, Pietro
神经元可以维持高速率的突触传递，而不会耗尽它们的突触囊泡供应。这种特性依赖于突触囊泡膜的高效局部内吞再循环，其可以重复用于数百个，可能数千个外吞-内吞循环。在过去的四十年中，形态学，生理学，分子和遗传学研究提供了对膜交通反应的深入了解，这些反应控制着这种再循环及其调节。这些研究表明，突触囊泡内吞利用基本的和一般的内吞机制，但也涉及神经元特异性适应这些机制。因此，对这些过程的研究不仅推进了突触传递领域，而且更普遍地推进了内吞作用领域。本文总结了目前的信息突触囊泡内吞作用的基础上的分子机制的重点，并特别关注网格蛋白介导的内吞作用，突触囊泡蛋白内化的主要途径。
Neurons can sustain high rates of synaptic transmission without exhausting their supply of synaptic vesicles. This property relies on a highly efficient local endocytic recycling of synaptic vesicle membranes, which can be reused for hundreds, possibly thousands, of exo-endocytic cycles. Morphological, physiological, molecular, and genetic studies over the last four decades have provided insight into the membrane traffic reactions that govern this recycling and its regulation. These studies have shown that synaptic vesicle endocytosis capitalizes on fundamental and general endocytic mechanisms but also involves neuron-specific adaptations of such mechanisms. Thus, investigations of these processes have advanced not only the field of synaptic transmission but also, more generally, the field of endocytosis. This article summarizes current information on synaptic vesicle endocytosis with an emphasis on the underlying molecular mechanisms and with a special focus on clathrin-mediated endocytosis, the predominant pathway of synaptic vesicle protein internalization.