Towards a long-term model construction for the dynamic simulation of hiv infection
Towards a long-term model construction for the dynamic simulation of hiv infection
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DOI：
10.3934/mbe.2007.4.489
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发表时间：
2007-07-01
影响因子：
2.6
通讯作者：
Vassiliadis, Vassilis S.
中科院分区：
文献类型：
--
作者：
Hadjiandreou, M.;Conejeros, Raul;Vassiliadis, Vassilis S.
这项研究涉及艾滋病毒长期动态的数学建模。所提出的模型能够预测疾病的整个轨迹：感染最初几周的初始病毒血症，潜伏期和进展到艾滋病;范围跨越约10年。模型结果与临床数据进行了比较，并取得了显着的一致性。制定的模型考虑了所有重要的人口区室，包括巨噬细胞，潜在感染的CD4 + T细胞，细胞毒性T淋巴细胞（CTL），在许多方面是新的尝试在艾滋病毒建模领域。模型参数和初始条件的范围是从文献中获得的，其值在这项工作中直接通过拟合已发表的临床数据来确定。此外，模拟结果强调了巨噬细胞在HIV感染和进展为AIDS中的重要性，并显示了CTL水平与HIV进展之间的明显相关性。该模型关联分析数据的能力为其预测提供了可信度，这一事实将在未来的免疫学和药理学治疗途径建模研究中得到利用。
This study involves the mathematical modelling of long-term HIV dynamics. The proposed model is able to predict the entire trajectory of the disease: initial viremia in the early weeks of the infection, latency, and progression to AIDS; a range spanning approximately ten years. The model outcomes were compared to clinical data and significant agreement was achieved. The formulated model considers all important population compartments including macrophages, latently-infected CD4+ T-cells, and cytotoxic T-lymphocytes (CTLs), an attempt which in many respects is novel in the area of HIV modelling. The ranges of the model parameters and initial conditions were obtained from literature, and their values were determined in this work directly by fitting published clinical data. Furthermore, the simulation results emphasize the importance of macrophages in HIV infection and progression to AIDS and show a clear correlation between the level of CTLs and HIV progression. The ability of the model to correlate analytical data gives credibility to its predictions, a fact that will be exploited in future research in modelling immunological and pharmacological avenues of treatment.