Surface modification of silica core-shell nanocapsules: biomedical implications.
Surface modification of silica core-shell nanocapsules: biomedical implications.
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DOI：
10.1021/bm050820
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发表时间：
2006-02
影响因子：
6.2
通讯作者：
A. Jovanovic;J. Flint;M. Varshney;T. Morey;D. Dennis;R. Duran
中科院分区：
文献类型：
--
作者：
A. Jovanovic;J. Flint;M. Varshney;T. Morey;D. Dennis;R. Duran
本文介绍了不同壳厚的油芯硅壳纳米胶囊的合成。用聚乙烯氧化物（PEO）和丁二酸酐对纳米胶囊进行表面修饰。然后用两项生物医学试验来研究这些纳米胶囊在不同表面处理、溶血和血栓弹性成像（TEG）下的生物相容性。PEO表面修饰大大降低了纳米胶囊与红细胞和血小板的破坏性相互作用，并减弱了粒径效应。结果发现，带电粒子的血液毒性随其表面酸强度的增加而增加。目前正在进行实验，以评估这些纳米胶囊在模型药物过量浓度下的解毒作用。
In this article we present the synthesis of oil core silica shell nanocapsules with different shell thicknesses. The surface of the nanocapsules was modified with polyethyleoxide (PEO) and succinic anhydride. Two biomedical tests were then used to study the biocompatibility properties of these nanocapsules with different surface treatments, hemolysis and thromboelastography (TEG). PEO surface modification greatly reduced the damaging interactions of nanocapsules with red blood cells (RBCs) and platelets and attenuated particle size effects. It was found that the blood toxicity of charged particles increased with the acid strength on the surface. Experiments toward the assessment of detoxification of these nanocapsules in model drug overdose concentrations are currently underway.