Novel cytotoxic chalcones from Litsea rubescens and Litsea pedunculata
Novel cytotoxic chalcones from Litsea rubescens and Litsea pedunculata
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来自冬凌草和带柄木姜子的新型细胞毒性查耳酮
DOI：
10.1016/j.bmcl.2011.10.003
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发表时间：
2011-12-15
影响因子：
2.7
通讯作者：
Zhang, Hong-Bing
中科院分区：
文献类型：
--
作者：
Li, Liang;Zhao, Xing-Tang;Zhang, Hong-Bing
Two novel flavonoids with chalcone skeleton, together with seven known flavonoids, were isolated from the stem barks of Litsea rubescens and Litsea pedunculata. The structures of the new compounds were elucidated on the basis of spectral methods including IR, UV, 1D and 2D NMR. The new chalcones were found to contain the rare epoxy or ethylidenedioxy group. This is the first report on the presence of chalcone in the plant genus Litsea. The cytotoxic potential of two new chalcones was evaluated in vitro against three human tumor cell lines. Both new chalcones displayed potent cytotoxic activities against myeloid leukaemia (HL-60) and epidermoid carcinoma (A431) cell lines and more active than cisplatin (DDP). Interestingly, compound 1 exhibited cytotoxic activity against HL-60 with IC50 value 2.1-fold more sensitive to DDP. (C) 2011 Elsevier Ltd. All rights reserved.
