Gamma Oscillations in the Basolateral Amygdala: Biophysical Mechanisms and Computational Consequences
Gamma Oscillations in the Basolateral Amygdala: Biophysical Mechanisms and Computational Consequences
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DOI：
10.1523/eneuro.0388-18.2018
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发表时间：
2019-01-01
期刊：
影响因子：
3.4
通讯作者：
Nair, Satish S.
中科院分区：
文献类型：
--
作者：
Feng, Feng;Headley, Drew B.;Nair, Satish S.
杏仁核的基底外侧核（BL）被认为通过特定的微电路支持许多情绪行为。这些通常被认为是由主细胞（PN）和中间神经元的前馈网络组成。周期性和反馈连接既没有被充分理解，也没有被经常考虑，这可能会在BL内产生振荡动态。事实上，已知在BL中发生伽马频率范围（40 - 100 Hz）的振荡，但它们的起源和对局部电路的影响仍然未知。为了解决这个问题，我们构建了一个生物解剖学和解剖学上详细的模型，大鼠BL和其局部场电位（LFP）的基础上的生理和解剖学文献，沿着在体内和体外的数据，我们收集的活动，在大鼠BL内的神经元。值得注意的是，该模型产生了间歇性的伽马振荡（类似于50 - 70 Hz），其特性与体内记录的特性相匹配，包括它们的尖峰夹带。BL γ-波段振荡由内在电路产生，取决于PN和快速尖峰中间神经元（FSI）之间的相互作用，而这些细胞类型内的连接影响节律的频率。该模型使我们能够进行实验上不可能的测试，以表征伽马的突触和空间特性。个别神经元的夹带伽玛依赖于他们收到的传入连接的数量，和伽玛爆发空间限制在BL。重要的是，γ节律同步PN和介导的合奏之间的竞争。总之，这些结果表明，BL的经常性连接扩展了其计算和通信的剧目。
The basolateral nucleus of the amygdala (BL) is thought to support numerous emotional behaviors through specific microcircuits. These are often thought to be comprised of feedforward networks of principal cells (PNs) and interneurons. Neither well-understood nor often considered are recurrent and feedback connections, which likely engender oscillatory dynamics within BL. Indeed, oscillations in the gamma frequency range (40 - 100 Hz) are known to occur in the BL, and yet their origin and effect on local circuits remains unknown. To address this, we constructed a biophysically and anatomically detailed model of the rat BL and its local field potential (LFP) based on the physiological and anatomical literature, along with in vivo and in vitro data we collected on the activities of neurons within the rat BL. Remarkably, the model produced intermittent gamma oscillations (similar to 50 - 70 Hz) whose properties matched those recorded in vivo, including their entrainment of spiking. BL gamma-band oscillations were generated by the intrinsic circuitry, depending upon reciprocal interactions between PNs and fast-spiking interneurons (FSIs), while connections within these cell types affected the rhythm's frequency. The model allowed us to conduct experimentally impossible tests to characterize the synaptic and spatial properties of gamma. The entrainment of individual neurons to gamma depended on the number of afferent connections they received, and gamma bursts were spatially restricted in the BL. Importantly, the gamma rhythm synchronized PNs and mediated competition between ensembles. Together, these results indicate that the recurrent connectivity of BL expands its computational and communication repertoire.