Diffusional support of arteries.
Diffusional support of arteries.
复制标题
动脉的扩散支持。
DOI：
10.1152/ajpheart.1985.248.6.h901
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Heistad,DD
中科院分区：
文献类型：
--
作者：
Werber,AH;Heistad,DD
动脉管腔、外膜血管和内侧血管在动脉营养支持中的相对作用尚不清楚。我们使用了一种新开发的放射自显影方法来研究代谢惰性[14C]安替比林在动脉中的扩散，以确定不同途径在动脉营养支持中的相对重要性。[14C]在15个S内，安替比林在各小动脉中层均一分布，表明安替比林向中央中层扩散较快。胸、腹主动脉内中膜安替比林含量高于中膜中层(P<0.05)。胸主动脉(含内、外膜血管)外中膜安替比林水平与内中膜相当，但腹主动脉外中膜安替比林水平低于腹主动脉内中膜(仅有外膜血管)。肋间动脉是胸主动脉内侧血管的来源，结扎肋间动脉减少了对胸主动脉外中膜的弥散支持。我们得出的结论是：1)弥散支持在较细的肌肉动脉中比在主动脉中更有效，2)腔内和腔内营养来源都很重要，特别是对主动脉，3)血管似乎对胸主动脉中膜的充分扩散支持很重要，4)内侧血管可能比外膜血管更有效地滋养主动脉。
The relative role of the arterial lumen, adventitial vasa vasorum, and medial vasa vasorum in nutritional support of arteries is unclear. We have used a newly developed autoradiographic method to study diffusion of metabolically inert [14C]antipyrine into arteries to determine the relative importance of different pathways in nutritional support of arteries. [14C]antipyrine was homogenously distributed across the media of small arteries within 15 s, which indicates that diffusion into the central media was rapid. In the thoracic and abdominal aorta, levels of antipyrine were higher in the inner media (P less than 0.05) than in the middle of the media. Levels of antipyrine in outer media of the thoracic aorta (which has medial and adventitial vasa) were comparable to those observed in the inner media, but antipyrine levels were lower in outer than in inner media of the abdominal aorta (which has adventitial vasa only). Ligation of intercostal arteries, which are the source of medial vasa vasorum in the thoracic aorta, decreased diffusional support to the outer media of the thoracic aorta. We conclude that 1) diffusional support is more effective in thinner muscular arteries than in the aorta, 2) both luminal and abluminal sources of nutrition are important, particularly for the aorta, 3) vasa vasorum appear to be important for adequate diffusional support of the thoracic aortic media, and 4) medial vasa vasorum may be more effective than adventitial vasa vasorum in nourishing the aorta.