Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders.
Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders.
复制标题
排除突触小泡单胺转运蛋白基因座与精神分裂症谱系疾病之间的密切联系。
DOI：
10.1002/ajmg.1320600616
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Crowe,RR
中科院分区：
文献类型：
--
作者：
Persico,AM;Wang,ZW;Black,DW;Andreasen,NC;Uhl,GR;Crowe,RR
The principal brain synaptic vesicular monoamine transporter (VMAT2) is responsible for the reuptake of serotonin, dopamine, nor‐epinephrine, epinephrine, and histamine from the cytoplasm into synaptic vesicles, thus contributing to determination of the size of releasable neurotransmitter vesicular pools. Potential involvement of VMAT2 gene variants in the etiology of schizophrenia and related disorders was tested using polymorphic VMAT2 gene markers in 156 subjects from 16 multiplex pedigrees with schizophrenia, schizophreniform, schizoaffective, and schizotypal disorders and mood incongruent psychotic depression. Assuming genetic homogeneity, complete (θ = 0.0) linkage to the schizophrenia spectrum was excluded under both dominant and recessive models. Allelic variants at the VMAT2 locus do not appear to provide major genetic contributions to the etiology of schizophrenia spectrum disorders in these pedigrees. © 1995 Wiley‐Liss, Inc.
