Chemical implant fixation using hydroxyl-apatite coatings. The development of a human total hip prosthesis for chemical fixation to bone using hydroxyl-apatite coatings on titanium substrates.
Chemical implant fixation using hydroxyl-apatite coatings. The development of a human total hip prosthesis for chemical fixation to bone using hydroxyl-apatite coatings on titanium substrates.
复制标题
使用羟基磷灰石涂层进行化学植入固定。
DOI：
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发表时间：
1987
影响因子：
4.2
通讯作者：
CHRISTEL P.A. T. KLEIN
中科院分区：
文献类型：
--
作者：
R. Geesink;KLAAS DE Groot;CHRISTEL P.A. T. KLEIN
烧结羟基磷灰石植入物与活体骨形成非常紧密的粘结，但容易疲劳失效。钛衬底上的等离子喷涂磷灰石涂层克服了疲劳问题。磷灰石涂层的静态拉伸结合强度超过85兆帕斯卡(兆帕)(12,000磅/平方英寸)。在一项旨在消除机械固位的插入式种植体研究中，获得了兆帕(9280psi)的骨结合剪切强度，与皮质骨的强度相当。组织学切片证实了磷灰石涂层与活骨之间的紧密结合。在一项犬全髋关节置换术研究中，磷灰石涂层的植入物被证明远远优于未涂层的对照组。未涂覆的假体被纤维组织包围，术后任何时候都很容易从股骨中取出。磷灰石涂层的种植体在三周内被刚性固定，直到种植体表面有明显的骨形成。6周内，深达2 mm的骨缺损处被骨填充。骨结合的假设机制是化学作用。羟基磷灰石涂层使种植体固定远远优于目前使用粘结剂或非粘固剂技术的方法。该计划是研究一种用于骨的化学固定的羟基磷灰石涂层的人类全髋关节假体。
Sintered hydroxyl-apatite implants form very tight bonds with living bone but are susceptible to fatigue failure. Plasma-sprayed apatite coatings on titanium substrates overcome the fatigue problem. The static tensile substrate bond strength of the apatite coating is in excess of 85 megapascals (MPa) (12,000 psi). In a plug implant study designed to discount mechanical retention, a bone bonding shear strength of 64 MPa (9280 psi) was achieved, comparable to the strength of cortical bone. Histologic sections confirm the close bonding between apatite coating and living bone. In a canine total hip arthroplasty study, the apatite-coated implants proved far superior to the uncoated controls. Uncoated prostheses were surrounded by fibrous tissue and were easily extracted from the femur at any postoperative time. The apatite-coated implants were rigidly fixed within three weeks with demonstrable bone formation up to the implant surface. Bony defects up to 2 mm in depth were filled with bone within six weeks. The hypothetical mechanism of bone bonding is chemical. Hydroxyl-apatite coatings permit an implant fixation far superior to current methods using either cemented or cementless techniques. The plan is to study a human total hip prosthesis with hydroxyl-apatite coating for chemical fixation to bone.