LACTATION AND RISK OF BREAST-CANCER IN A COHORT OF UNITED-STATES WOMEN
LACTATION AND RISK OF BREAST-CANCER IN A COHORT OF UNITED-STATES WOMEN
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DOI：
10.1093/oxfordjournals.aje.a115629
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发表时间：
1990-07-01
影响因子：
5
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
--
作者：
LONDON, SJ;COLDITZ, GA;SPEIZER, FE
1976年，对89,413名年龄在30-55岁且未患癌症的美国注册分娩女护士进行了队列调查，研究了哺乳与乳腺癌风险之间的关系。这些护士提供了1986年总哺乳期的信息。1976至1986年间，在785,958人年的随访中，发生了1262例乳腺癌。哺乳和患乳腺癌的风险之间没有独立的联系。在调整年龄和胎次后，与从未哺乳的妇女相比，哺乳7个月、7~11个月、12~23个月、12~23个月、12~23个月的相对危险度分别为0.95(95%CI 0.84~1.08)、0.87(95%CI 0.71~1.08)、0.94(95%CI 0.77~1.14)、0.98(95%CI 0.76~128)。24个月(趋势检验：Z=-8.80，p=0.42)。这种关联并不因年龄或绝经状态而异。这些结果并不能证实较短的哺乳期会降低年轻女性患乳腺癌风险的报道。
The relation between lactation and risk of breast cancer was examined in a cohort of 89,413 parous female US registered nurses aged 30-55 years and free from cancer in 1976 who provided information on total duration of lactation in 1986. Between 1976 and 1986, 1,262 cases of breast cancer occurred during 785,958 person-years of follow-up. There was no independent association between lactation and the risk of breast cancer. After adjustment for age and parity, compared with women who had never lactated, the relative risks (and 95% confidence intervals (CI)) were 0.95 (95% CI 0.84-1.08) for women with < 7 months of lactation, 0.87 (95% CI 0.71-1.08) for 7-11 months, 0.94 (95% Cl 0.77-1.14) for 12-23 months, and 0.98 (95% Cl 0.76-128) for .gtoreq. 24 months (test for trend: z = -8.80, p = 0.42). The association did not differ by age or menopausal status. These results do not confirm reports that relatively short durations of lactation reduce the risk of breast cancer among younger women.