Dual-Sensitized Luminescent Europium() and Terbium() Complexes as Bioimaging and Light-Responsive Therapeutic Agents
Dual-Sensitized Luminescent Europium() and Terbium() Complexes as Bioimaging and Light-Responsive Therapeutic Agents
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DOI：
10.1002/chem.201603453
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发表时间：
2016-11-21
影响因子：
4.3
通讯作者：
Patra, Ashis K.
中科院分区：
文献类型：
--
作者：
Dasari, Srikanth;Singh, Swati;Patra, Ashis K.
设计了双光敏稳定的Eu和Tb配合物[Eu（dpq）（tfnb）（3）]（1）和[Tb（dpq）（tfnb）（3）]（2），其中dpq=联吡啶并[3，2-d：2，3-f]喹喔啉，Htfnb= 4，4，4-三氟-1-（2-萘基）-1，3-丁二酮，作为生物成像剂和光响应治疗剂。研究了它们的X射线结构、光物理性质、生物相互作用、光诱导DNA损伤、光细胞毒性和细胞吸收性质。单核配合物采用八配位{LnN（2）O（6）}畸变正方反棱柱几何构型，配体为双齿N，N-dpq和O，O-tfnb。所设计的探针具有双敏化天线（dpq，Htfnb）的优点，以调节其所需的光学特性，用于细胞成像和光响应的细胞内损伤。显着的光稳定性，不存在内球水（q
Dual-photosensitized stable Eu and Tb complexes, namely [Eu(dpq)(tfnb)(3)] (1) and [Tb(dpq)(tfnb)(3)] (2), in which dpq=dipyrido[3,2-d:2,3-f]quinoxaline and Htfnb=4,4,4-trifluoro-1-(2-napthyl)-1,3-butanedione, were designed as bioimaging and light-responsive therapeutic agents. Their X-ray structures, photophysical properties, biological interactions, photoinduced DNA damage, photocytotoxicity, and cellular uptake properties were studied. Discrete mononuclear complexes adopt an eight-coordinated {LnN(2)O(6)} distorted square antiprism geometry with bidentate N,N-donor dpq and O,O-donor tfnb ligands. The designed probes have the advantage of dual-sensitizing antennae (dpq, Htfnb) to modulate their desirable optical properties for cellular imaging and light-responsive intracellular damage. The remarkable photostability, absence of inner-sphere water (q