EVIDENCE FOR THE EFFECTS OF A SUPERANTIGEN IN RHEUMATOID-ARTHRITIS
EVIDENCE FOR THE EFFECTS OF A SUPERANTIGEN IN RHEUMATOID-ARTHRITIS
复制标题
DOI：
10.1126/science.1857971
复制
发表时间：
1991-07-19
期刊：
影响因子：
56.9
通讯作者：
KOTZIN, BL
中科院分区：
文献类型：
--
作者：
PALIARD, X;WEST, SG;KOTZIN, BL
在研究类风湿性关节炎（RA）患者的α-β T细胞受体库时，我们发现受影响关节的滑液中V-β-14 + T细胞的频率显著高于外周血。事实上，在大多数RA患者的外周血中几乎检测不到V-β-14 + T细胞。β-链序列表明，一个或几个克隆占主导地位的V-β-14+群体在个别RA患者的滑液，而寡克隆性是不太明显的其他V-β和V-β-14在其他类型的炎性关节炎。这些结果暗示了携带V-β-14的T细胞在RA的病理学中。他们还表明，RA的病因可能涉及V-β-14特异性超抗原对V-β-14 + T细胞的初始激活，随后将少数激活的自身反应性V-β-14 + T细胞克隆募集到关节，而大多数其他V-β-14 + T细胞消失。
While studying the alpha-beta T cell receptor repertoire in rheumatoid arthritis (RA) patients, we found that the frequency of V-beta-14+ T cells was significantly higher in the synovial fluid of affected joints than in the peripheral blood. In fact, V-beta-14+ T cells were virtually undetectable in the peripheral blood of a majority of these RA patients. beta-chain sequences indicated that one or a few clones dominated the V-beta-14+ population in the synovial fluid of individual RA patients, whereas oligoclonality was less marked for other V-beta's and for V-beta-14 in other types of inflammatory arthritis. These results implicate V-beta-14-bearing T cells in the pathology of RA. They also suggest that the etiology of RA may involve initial activation of V-beta-14+ T cells by a V-beta-14-specific superantigen with subsequent recruitment of a few activated autoreactive V-beta-14+ T cell clones to the joints while the majority of other V-beta-14+ T cells disappear.