Factors modulating the interaction of LDL with an arterial lipoprotein complexing proteoglycan: the effect of HDL.
Factors modulating the interaction of LDL with an arterial lipoprotein complexing proteoglycan: the effect of HDL.
复制标题
调节 LDL 与动脉脂蛋白复合蛋白聚糖相互作用的因素：HDL 的作用。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
L. Socorro
中科院分区：
文献类型：
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作者：
G. Camejo;M. M. Cortez;F. López;R. Starosta;B. Mosquera;L. Socorro
人动脉内膜/中膜提取物中存在一种脂蛋白复合体蛋白多糖(LCP)，它与低密度脂蛋白(LDL)形成特异的复合体，提示它可能在低密度脂蛋白与动脉壁相互作用和动脉粥样硬化形成过程中发挥作用。血清与动脉提取液孵育形成的不溶性低密度脂蛋白-低密度脂蛋白复合体与低密度脂蛋白浓度呈正相关，与高密度脂蛋白含量呈负相关，提示高密度脂蛋白可能抑制低密度脂蛋白与低密度脂蛋白的相互作用。在含有LCP的提取物与低密度脂蛋白孵育之前，通过向其添加高密度脂蛋白，这种抑制作用明显可见。这种效应在载脂蛋白高密度脂蛋白上也有表现，但在无脂蛋白血浆中没有表现出来。提示血浆穿过内皮屏障的高密度脂蛋白/低密度脂蛋白比值可能是低密度脂蛋白在动脉内膜/中膜净积聚及其在动脉粥样硬化形成中的作用的重要调节因子。
The presence of a lipoprotein complexing proteoglycan (LCP) in extracts of human arterial intima/media that forms specific complexes with low density lipoproteins (LDL) has suggested that it may play a role in the interaction of LDL with the arterial wall and the atherogenic process. The formation of insoluble LDL-LCP complexes by incubation of serum with arterial extracts appears directly related to the concentration of LDL and inversely to the content of high density lipoproteins (HDL), indicating that HDL may inhibit the interaction between LDL and LCP. This inhibition is clearly visible by addition of HDL to LCP containing extracts before their incubation with LDL. This effect is also shown by apoHDL but not by lipoprotein-free plasma. It is suggested that the HDL/LDL ratio of the plasma crossing the endothelial barrier may be an important modulator of the net accumulation of LDL in the intima/media and of its contribution to atherogenesis.