The incidence and course of retinopathy of prematurity: Findings from the early treatment for retinopathy of prematurity study
The incidence and course of retinopathy of prematurity: Findings from the early treatment for retinopathy of prematurity study
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DOI：
10.1542/peds.2004-1413
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发表时间：
2005-07-01
期刊：
影响因子：
8
通讯作者：
Good, WV
中科院分区：
文献类型：
--
作者：
Good, WV
目标。旨在估计早产儿视网膜病变早期治疗 (ETROP) 研究中早产儿视网膜病变 (ROP) 的发生率，并将这些结果与早产儿视网膜病变冷冻疗法 (CRYO-ROP) 研究中报告的结果进行比较。方法。作为其方案的一部分，ETROP 研究对美国 26 个中心的 6998 名婴儿进行了筛查。对出生体重 < 1251 克的婴儿进行了一系列眼部检查，从而可以估计不同出生体重和胎龄类别中 ROP 的频率。 ROP 根据 ROP.Result 国际分类进行分类。体重 < 1251 g 的婴儿中任何 ROP 的发生率为 68%。研究结果与 CRYO-ROP 研究中 1986 年和 1987 年出生的婴儿的结果进行了比较。两项研究中 ROP 的总体发生率相似，但 ETROP 研究中 I 区 ROP 较多。在患有 ROP 的婴儿中，ETROP 研究中 36.9% 的婴儿发生了更严重的 ROP（阈值前），而 CRYO-ROP 研究中 27.1% 的婴儿发生了更严重的 ROP（阈值前）。自CRYO-ROP研究开展以来，不同严重程度的ROP发病孕龄变化很小。结论。 ROP 仍然是出生体重 < 1251 克的婴儿中常见的重要问题。自 CRYO-ROP 自然史研究以来，ROP 的发生率、发病时间、进展率和阈值前疾病的发病时间几乎没有变化。
Objectives. To estimate the incidence of retinopathy of prematurity (ROP) in the Early Treatment for Retinopathy of Prematurity (ETROP) Study and compare these results with those reported in the Cryotherapy for Retinopathy of Prematurity (CRYO- ROP) Study.Methods. The ETROP Study, as part of its protocol, screened 6998 infants at 26 centers throughout the United States. Serial eye examinations were conducted for infants born weighing < 1251 g, making it possible to estimate the frequency of ROP in different birth weight and gestational age categories. ROP was categorized according to the International Classification for ROP.Results. The incidence of any ROP was 68% among infants of < 1251 g. The findings were compared with those for infants born in 1986 and 1987 in the CRYO-ROP Study. The overall incidences of ROP were similar in the 2 studies, but there was more zone I ROP in the ETROP Study. Among infants with ROP, more-severe ROP (pre-threshold) occurred for 36.9% of infants in the ETROP Study and 27.1% of infants in the CRYO-ROP Study. The gestational age of onset of ROP of different severities has changed very little since the CRYO-ROP Study was conducted.Conclusions. ROP remains a common important problem among infants with birth weights of < 1251 g. The incidence of ROP, time of onset, rate of progression, and time of onset of prethreshold disease have changed little since the CRYO- ROP natural- history study.