Attitudes and perceptions of patients towards methods of establishing a DNA biobank
Attitudes and perceptions of patients towards methods of establishing a DNA biobank
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DOI：
10.1007/s10561-007-9051-2
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发表时间：
2008-03-01
影响因子：
1.5
通讯作者：
Masys, Dan R.
中科院分区：
文献类型：
--
作者：
Pulley, Jill M.;Brace, Margaret M.;Masys, Dan R.
背景：这项研究旨在评估患者的态度，作为大规模从多余的临床血液样本中收集基因样本进行研究的计划过程的一部分(DNA数据库项目)。方法随机抽取5000名住院患者、门诊患者和急诊科患者，邮寄一份包含38个项目的预测问卷。结果约20%的患者有反应(n=1003)。大多数人对匿名遗传信息用于研究感到满意(89.3%)，并支持潜在的好处(98.7%)。对DNA计划舒适度的二元逻辑回归表明，受访者对该计划感觉的差异可以用信念、年龄和健康状况来最好地解释。受访者基本上被分成5个不同的类别。结论这些数据表明被调查者普遍接受，但一部分人会反对该计划。这加强了广泛和持续地与患者就该计划和排除给定样本的能力进行沟通的必要性。先前信念的影响将从进一步的探索中受益。
Background This study aimed to assess patient attitudes as part of the planning process for a large-scale effort to collect genetic samples for research from excess clinical blood specimens ('DNA Databank' project). Method A pre-tested, 38-item questionnaire was mailed to a random sample of 5,000 inpatients, outpatients, and emergency department patients. Results Approximately 20% of patients responded (n = 1003). Most were comfortable with anonymized genetic information being used for research (89.3%) and supported the potential benefits (98.7%). A binary logistic regression on the level of comfort with the DNA program shows that the variability in respondents' feelings about the program can best be explained by beliefs, age, and health status. Respondents were attitudinally segmented into 5 distinct categories. Conclusions These data indicate general acceptance among respondents, but a subset of the population would be opposed to the program. This reinforces the need to broadly and continuously communicate with patients about the program and the ability to exclude a given sample. The effects of prior beliefs would benefit from further exploration.