Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.
Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.
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DOI：
10.3233/jad-140798
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Pham W
中科院分区：
文献类型：
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作者：
McClure R;Yanagisawa D;Stec D;Abdollahian D;Koktysh D;Xhillari D;Jaeger R;Stanwood G;Chekmenev E;Tooyama I;Gore JC;Pham W
姜黄素是一种很有前途的化合物，可以作为一种治疗剂来帮助研究阿尔茨海默病。除了能与淀粉样斑块结合外，这种化合物还能穿过血脑屏障。目前，姜黄素只能应用于动物模型，因为静脉注射所需的配方使其不适合人类使用。在这里，我们描述了一种雾化姜黄素衍生物FMeC1并促进其安全递送到大脑的新技术。除了这种方法的翻译适用性，一项在5XFAD小鼠模型中的研究表明，吸入暴露于雾化的FMeC1适度改善了该化合物在大脑中的分布。此外，免疫组织化学数据证实，在气溶胶递送后，FMeC1结合了海马区和皮层中表达的淀粉样斑块。
Curcumin is a promising compound that can be used as a theranostic agent to aid research in Alzheimer’s disease. Beyond its ability to bind to amyloidal plaques, the compound can also cross the blood brain barrier. Presently, curcumin can be applied only to animal models, as the formulation needed for iv injection renders it unfit for human use. Here, we describe a novel technique to aerosolize a curcumin derivative, FMeC1 and facilitate its safe delivery to the brain. Aside from the translational applicability of this approach, a study in the 5XFAD mouse model suggested that inhalation exposure to an aerosolized FMeC1 modestly improved the distribution of the compound in the brain. Additionally, immunohistochemistry data confirms that following aerosol delivery, FMeC1 binds amyloidal plaques expressed in the hippocampal areas and cortex.