Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women
Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women
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DOI：
10.1016/j.psyneuen.2007.03.008
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发表时间：
2007-06-01
影响因子：
3.7
通讯作者：
Linden Hirschberg, A.
中科院分区：
文献类型：
--
作者：
Naessen, S.;Carlstrom, K.;Linden Hirschberg, A.
神经性贪食症女性的高雄激素水平可能会促进贪食行为。本研究的目的是研究抗雄激素口服避孕药（OC）对神经性贪食症女性食欲和饮食行为的影响，并与健康对照组进行比较。21名患有神经性贪食症的女性和17名年龄和体重指数相匹配的健康对照者参加了这项研究。在抗雄激素OC （30 μ g炔雌醇联合3 mg屈螺酮）治疗3个月前后，研究了基础和进餐相关的食欲和饱腹肽胆囊收缩素（CCK）和食欲刺激肽胃饥饿素的分泌。暴食行为与激素水平的变化有关。在治疗前，暴食症女性出现月经紊乱、痤疮和多毛的频率更高，睾酮水平更高，但与肉类相关的CCK分泌量比对照组高。OC治疗减少了暴食症患者与肉类相关的饥饿和胃胀。CCK分泌对肉的反应在暴食症妇女中没有变化，但在对照组中有所下降。胃饥饿素分泌在两组之间具有可比性，并且对OC治疗没有反应。治疗改善了暴食行为，这与整个小组睾酮水平的下降有关。我们的研究结果支持了雄激素在暴食行为中起作用的建议。抗雄激素OC治疗可作为治疗神经性贪食症的新策略，特别是对那些有高雄激素症状的患者。(C) 2007 Elsevier Ltd.版权所有。
High androgen levels in women with bulimia nervosa may promote bulimic behavior. The aim of the present study was to investigate the effects of an antiandrogenic oral contraceptive (OC) on appetite and eating behavior in women with bulimia nervosa compared to healthy controls. Twenty-one women with bulimia nervosa and 17 healthy controls matched for age and body mass index participated in the study. Basal and meal-related appetite and secretions of the satiety peptide cholecystokinin (CCK) and the appetite-stimulating peptide ghrelin were studied before and after 3 months of treatment with an antiandrogenic OC (30 mu g ethinyl estradiol combined with 3 mg drospirenone). Bulimic behavior was evaluated in relation to changes in hormone levels. Before treatment, bulimic women had higher frequency of menstrual disturbances, acne and hirsutism and higher levels of testosterone but tower meat-related CCK secretion than controls. OC treatment reduced meat-related hunger and gastric distention in bulimics. CCK secretion in response to the meat was unchanged in bulimic women but decreased in the controls. Ghrelin secretion was comparable between groups and did not change in response to OC treatment. The treatment improved bulimic behavior in relation to a decline in testosterone levels in the entire group. Our results support the suggestion that androgens play a role in bulimic behavior. Treatment with an antiandrogenic OC may serve as a new strategy for treatment of bulimia nervosa and particularly in those patients with hyperandrogenic symptoms. (C) 2007 Elsevier Ltd. All rights reserved.