ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy.
ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy.
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DOI：
10.1111/cas.12560
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发表时间：
2015-01
期刊：
影响因子：
5.7
通讯作者：
Noh DY
中科院分区：
文献类型：
--
作者：
Kim HJ;Im SA;Keam B;Ham HS;Lee KH;Kim TY;Kim YJ;Oh DY;Kim JH;Han W;Jang IJ;Kim TY;Park IA;Noh DY
三磷酸腺苷结合盒B1（ABCB 1）转运蛋白和P-糖蛋白的表达与抗癌药物的耐药性有关。本研究旨在探讨ABCB 1和CYP 3A基因单核苷酸多态性在乳腺癌新辅助化疗患者中的作用。II/III期乳腺癌患者接受了3个周期的新辅助治疗，之后患者接受了根治性手术和辅助化疗。对ABCB 1和CYP 3A基因多态性进行基因分型。分析ABCB 1、CYP 3A基因多态性与临床结局的相关性。在216例患者中，ABCB 1 3435 TT基因型具有较长的总生存期（OS）。比CC/CT。多因素分析表明，良好的PS、浸润性导管癌、非三阴性表型和初始可手术期与较低的死亡风险显著相关。对于多西他赛，ABCB 1 3435 TT基因型的AUC高于CC/CT。C3435 TT中AUC较高与中性粒细胞减少症和腹泻毒性增加相关。本研究表明ABCB 1基因C3435 T多态性可能与较长的OS相关。我们的研究结果还表明，C3435 T多态性可能预测多西他赛的毒性。该研究结果为根据基因型进行个体化治疗提供了有价值的信息。
Expression of the adenosine triphosphate-binding cassette B1 (ABCB1) transporter and P-glycoprotein are associated with resistance to anticancer drugs. The purpose of this study was to investigate the role of single nucleotide polymorphism in the ABCB1 and CYP3A genes in breast cancer patients who were treated with neoadjuvant chemotherapy. Stage II/III breast cancer patients were treated with three cycles of neoadjuvant, after which the patients received curative surgery and adjuvant chemotherapy. The polymorphisms of ABCB1 and CYP3A were genotyped. The correlation of polymorphism of ABCB1, CYP3A, and clinical outcomes was analyzed. Among the 216 patients, ABCB1 3435TT genotype had a longer overall survival (OS). than CC/CT. Multivariate analyses demonstrated that good PS, invasive ductal carcinoma, non-triple negative phenotype and initial operable stage were significantly associated with a lower death risk. ABCB1 3435TT genotype had a higher AUC than CC/CT for docetaxel. These higher AUCs in the C3435TT was associated with increased toxicities of neutropenia and diarrhea. This study showed that the genetic polymorphism of ABCB1 C3435T might be associated with a longer OS. Our results also suggest that the prediction of docetaxel toxicity might be possible for C3435T polymorphism. This study results provides valuable information on individualized therapy according to genotypes.
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影响因子：
3
作者：
Puisset, F;Chatelut, E;Roché, H
通讯作者：
Roché, H
影响因子：
30.8
作者：
Kuehl, P;Zhang, J;Schuetz, E
通讯作者：
Schuetz, E
DOI：
10.1097/00008571-200207000-00003
发表时间：
2002-07-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Spurdle, AB;Goodwin, B;Liddle, C
通讯作者：
Liddle, C
影响因子：
3.8
作者：
Han, Sehwan;Kim, Sung-Bae;Park, Hee-Sook
通讯作者：
Park, Hee-Sook
DOI：
10.1073/pnas.050585397
发表时间：
2000-03-28
影响因子：
11.1
作者：
Hoffmeyer, S;Burk, O;Brinkmann, U
通讯作者：
Brinkmann, U