Immunity-related genes and gene families in Anopheles gambiae
Immunity-related genes and gene families in Anopheles gambiae
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DOI：
10.1126/science.1077136
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发表时间：
2002-10-04
期刊：
影响因子：
56.9
通讯作者：
Kafatos, FC
中科院分区：
文献类型：
--
作者：
Christophides, GK;Zdobnov, E;Kafatos, FC
我们已经确定了242冈比亚按蚊基因涉及先天免疫的18个基因家族，并已检测到显着的多样化相对于果蝇。参与识别，信号调节和效应系统的免疫相关基因家族表现出显着的直系同源物和过度的基因扩增赤字，可能反映了选择压力，从不同的病原体在这些昆虫非常不同的生活方式。相反，多功能Toll信号转导途径基本上是保守的，大概是因为发育稳定性的反选择。代表性表达谱证实，序列多样化伴随着对不同免疫挑战的特异性应答。选择性RNA剪接也可能有助于扩大免疫库。
We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster. Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.