Manipulating Human Memory Through Reconsolidation: Stones Left Unturned.
Manipulating Human Memory Through Reconsolidation: Stones Left Unturned.
复制标题
通过重新巩固来操纵人类记忆：千方百计。
DOI：
10.1080/21507740.2016.1251989
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发表时间：
2016
影响因子：
--
通讯作者：
Diaz-Mataix,Lorenzo
中科院分区：
文献类型：
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作者：
Lázaro-Muñoz,Gabriel;Diaz-Mataix,Lorenzo
记忆重新巩固是指以前存储的记忆在被重新存储时变得不稳定并容易被修改的过程。巩固破坏方案（RDP）可能被证明是治疗涉及学习和记忆适应不良的精神疾病的强大治疗工具。然而，Elsey 和 Kindt（2016）对再巩固研究的现状进行了过于乐观和不完整的描述，这导致他们最大限度地减少了对通过再巩固来操纵人类记忆的科学和伦理担忧。这是有问题的，因为在评估将 RDP 转化为临床环境的潜在危害和益处时，他们对再巩固研究的描述可能会误导利益相关者，例如临床医生、患者和卫生政策制定者。我们针对作者对再巩固研究的描述提出了三个紧迫的担忧：（1）关于普萘洛尔 RDP 的有效性或临床实用性的证据不足且相互矛盾；（2）普萘洛尔 RDP 研究临时转化为临床实践的风险； (3) 缺乏对产生重大伦理挑战的其他类型的 RDP 的讨论——在对“通过重新巩固操纵人类记忆”这样广泛的主题得出伦理学结论时，有必要考虑不同类型的 RDP。
Memory reconsolidation is the process by which a previously stored memory, when recalled, becomes unstable and susceptible to modification before being re-stored. Reconsolidation disruption protocols (RDPs) may prove to be powerful therapeutic tools for psychiatric disorders that involve maladaptive learning and memory. However, Elsey and Kindt (2016) present an overly optimistic and incomplete portrayal of the state of reconsolidation research, which leads them to minimize scientific and ethical apprehensions about manipulating human memory through reconsolidation. This is problematic because their depiction of reconsolidation research could mislead stakeholders—such as clinicians, patients, and health policymakers—when evaluating the potential harms and benefits of translating RDPs to the clinical context. We address three pressing concerns about the authors’ depiction of reconsolidation research:(1) insufficient and contradictory evidence about the effectiveness or clinical utility of propranolol RDPs;(2) risk for extemporaneous translation of propranolol RDP research to clinical practice; and (3) lack of discussion of other kinds of RDPs that generate significant ethical challenges—it is necessary to consider different kinds of RDPs when drawing conclusions about the ethics of a topic as broad as “manipulating human memory through reconsolidation.”