Ultrasound Neuromodulation Inhibits Seizures in Acute Epileptic Monkeys
Ultrasound Neuromodulation Inhibits Seizures in Acute Epileptic Monkeys
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超声神经调节抑制急性癫痫猴的癫痫发作
DOI：
10.1016/j.isci.2020.101066
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发表时间：
2020-04
期刊：
影响因子：
5.8
通讯作者：
Zheng Hairong
中科院分区：
文献类型：
--
作者：
Zou Junjie;Meng Long;Lin Zhengrong;Qiao Yangzi;Tie Changjun;Wang Yibo;Huang Xiaowei;Yuan Tifei;Chi Yajie;Meng Wen;Niu Lili;Guo Yanwu;Zheng Hairong
最近，在对健康受试者进行的动物和人类研究中，超声波刺激已成为一种调节大脑活动的非侵入性方法。阿尔茨海默氏病、癫痫和抑郁症等脑部疾病是否可以使用超声波刺激来治疗仍需要探索。最近的研究报告称，超声刺激可抑制啮齿动物癫痫模型中的癫痫发作。这些发现提出了一个关键问题：超声刺激是否可以抑制非人灵长类癫痫患者的癫痫发作。在这里，我们解决了这个关键问题。我们证实超声刺激显着降低了急性癫痫猴的癫痫发作频率。此外，结果表明，超声刺激后癫痫发作的次数和持续时间减少，而癫痫发作间隔时间增加。此外，T2加权MR成像未观察到明显的脑组织损伤。我们的结果对于超声神经调节在癫痫患者中的未来临床应用具有重要意义。
Ultrasound stimulation has recently emerged as a non-invasive method for modulating brain activity in animal and human studies with healthy subjects. Whether brain diseases such as Alzheimer's disease, epilepsy, and depression can be treated using ultrasound stimulation still needs to be explored. Recent studies have reported that ultrasound stimulation suppressed epileptic seizures in a rodent model of epilepsy. These findings raise the crucial question of whether ultrasound stimulation can inhibit seizures in non-human primates with epilepsy. Here, we addressed this critical question. We confirmed that ultrasound stimulation significantly reduced the frequency of seizures in acute epileptic monkeys. Furthermore, the results showed that the number and duration of seizures were reduced, whereas the inter-seizure interval was increased after ultrasound stimulation. Besides, no significant brain tissue damage was observed by T2-weighted MR imaging. Our results are of great importance for future clinical applications of ultrasound neuromodulation in patients with epilepsy.
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