Severe chronic osteomyelitis caused by Morganella morganii with high population diversity.

Severe chronic osteomyelitis caused by Morganella morganii with high population diversity.
复制标题

由莫氏摩根氏菌引起的严重慢性骨髓炎,具有较高的种群多样性。

DOI:
10.1016/j.ijid.2016.07.016
复制
发表时间:
2016-09
期刊:
Int J Infect Dis
影响因子:
--
通讯作者:
Bai Fan
Bai Fan
中科院分区:
其他
文献类型:
--
作者:
Hou Shuxun;Ke Yuehua;Li Wenfeng;Bai Fan

文献摘要

参考文献

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本文报告1例可能由摩氏摩根菌引起的慢性骨髓炎,病程30余年。通过样品培养、直接测序和16S RNA基因扩增子测序的组合鉴定微生物。对患者分离株的进一步全基因组测序和群体结构分析显示,细菌群体具有高度多样性。这个病例提供了一个由机会致病菌M引起长期感染的有价值的例子。morganii,具有高度的多样性,这可能会在复制过程中在主机内进化。
A case of chronic osteomyelitis probably caused byMorganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen,M. morganii, with high diversity, which might evolve during replication within the host.
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