Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: the total synthesis (±)-cavidine
Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: the total synthesis (±)-cavidine
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DOI：
10.1016/j.tet.2014.04.066
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发表时间：
2014-10-07
期刊：
影响因子：
2.1
通讯作者：
Taylor, Richard J. K.
中科院分区：
文献类型：
--
作者：
Kitsiou, Christiana;Unsworth, William P.;Taylor, Richard J. K.
描述了一系列亚胺与邻位取代的苯甲酸衍生物的直接亚胺酰化（DIA）和随后的环化。偶联剂、亚胺和苯甲酸的变化均被检查。 DIA程序也被应用于(+/-)-卡维丁的全合成。 (C) 2014 Elsevier Ltd. 保留所有权利。
The direct imine acylation (DIA) and subsequent cyclisation of a range of imines with ortho-substituted benzoic acid derivatives is described. Variation in the coupling reagents, imine and benzoic acid were all examined. The DIA procedure was also applied in the total synthesis of (+/-)-cavidine. (C) 2014 Elsevier Ltd. All rights reserved.