The Advanced Glaucoma Intervention Study (AGIS): 3. Baseline characteristics of black and white patients.
The Advanced Glaucoma Intervention Study (AGIS): 3. Baseline characteristics of black and white patients.
复制标题
高级青光眼干预研究 (AGIS)：3. 黑人和白人患者的基线特征。
DOI：
10.1016/s0161-6420(98)97012-9
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发表时间：
1998
期刊：
影响因子：
13.7
通讯作者：
中科院分区：
文献类型：
--
作者：
本报告的目的是检查在晚期青光眼干预研究（AGIS）中登记的黑人和白人在基线时的人口统计学、医学和眼科特征的差异，AGIS是一项多中心、随机、对照的临床试验。（451只眼），249例白色患者（325只眼睛）和10名其他种族的开角型青光眼患者（13只眼睛），这些患者不能通过单独的药物治疗来控制。黑人和白色患者的眼科特征，调整了年龄和性别的比较。研究中的黑人比白人年轻，比白人有更多的系统性高血压和糖尿病。平均而言，黑人的视野缺陷比白人严重得多。两组的眼压和视力评分相似。黑人更远视，有相对较少的磁盘边缘discriminations比whites.CONCLUSIONSISThe目前的研究结果与以前的开角型青光眼的临床研究，视野缺损更严重的黑人比白人。
OBJECTIVEThe purpose of this report is to examine the differences at baseline in demographic, medical, and ophthalmic characteristics between blacks and whites enrolled in the Advanced Glaucoma Intervention Study (AGIS), a multicenter, randomized, clinical trial.DESIGNMulticenter, randomized, controlled trial.PARTICIPANTSA total of 332 black patients (451 eyes), 249 white patients (325 eyes), and 10 patients of other races (13 eyes) with open-angle glaucoma that could not be controlled by medical therapy alone participated.INTERVENTIONThere was no intervention performed.METHODSThe investigators compare the baseline demographic, medical, and ophthalmic characteristics of black and white patients, adjusting the comparisons for age and gender.RESULTSBlacks in the study were younger than whites and had more systemic hypertension and diabetes than whites. The visual field defects of blacks on average were substantially more severe than those of whites. Intraocular pressures and visual acuity scores were similar in the two groups. Blacks were more hyperopic and had relatively fewer disk rim hemorrhages than whites.CONCLUSIONSThe findings of the current study concur with those of previous clinical studies of open-angle glaucoma that visual field defects are more severe in blacks than whites.