An Extended Twin-Pedigree Study of Different Classes of Voluntary Exercise Behavior.
An Extended Twin-Pedigree Study of Different Classes of Voluntary Exercise Behavior.
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不同类别自愿运动行为的扩展双胞胎谱系研究。
DOI：
10.1007/s10519-019-09990-7
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发表时间：
2020
影响因子：
2.6
通讯作者：
deGeus,EJC
中科院分区：
文献类型：
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作者：
vanderZee,MatthijsD;Helmer,Q;Boomsma,DI;Dolan,CV;deGeus,EJC
我们调查了扩展双胞胎家系中不同类别的自愿规律锻炼行为的家庭聚集性。与早期仅基于双胞胎数据的工作相反，这使我们能够估计共享家庭效应(C)、可加性(A)和非可加性(D)遗传效应对自愿锻炼行为的贡献。为了测试共同的家庭效应是否会被分类交配夸大，我们调查了配偶相似的原因。对于荷兰双胞胎登记册中的青少年和成年参与者(16岁至65岁)，我们构建了19,543个家系，其中详细说明了登记册中核心家庭成员和大家庭之间的所有关系(N = 50,690人)。数据包括每周用于休闲运动的MET总分钟数，以及用于团队运动、单独运动、竞技运动、非竞争性运动、外部配速运动和内部配速运动的每周MET总分钟数。我们分析了Mendel软件包中的数据(Lange et al.在生物信息学29(12)：1568-1570,2013)中，根据家庭共享的多种定义，并使用来自双胞胎配偶的数据来测试表型分类、社会同婚和婚姻互动作为配偶相似性的潜在来源。结果证实了遗传因素对一生中每周锻炼行为总量的影响。广义遗传力为34-41%(A为19-26%，D为12-21%)，不依赖于家庭分享的定义。从事以团队为基础的、竞争性的、外部节奏的活动(如足球)比从事非竞争性的单独活动(如慢跑)的遗传性高 ~ 13%。作为兄弟姐妹同住一户可以解释成人锻炼行为差异的4%-8%，而配偶同住一户会产生更高的C估计(20%-24%)，因为它包含了配偶的相似之处。配偶相似性既可以用社会同性婚姻来解释，也可以用婚姻互动来解释，几乎没有表型分类的证据。我们的结论是，成年人自愿锻炼行为的数量和对特定类别锻炼活动的偏好都是由加性和非加性遗传因素以及包括配偶相关锻炼行为在内的独特环境影响来解释的。
We investigated the familial clustering of different classes of voluntary regular exercise behavior in extended twin-family pedigrees. In contrast to the earlier work based on twin data only, this allowed us to estimate the contributions of shared household effects (C), additive (A), and non-additive (D) genetic effects on voluntary exercise behavior. To test whether shared household effects were inflated by assortative mating we examined the causes of spousal resemblance. For adolescent and adult participants (aged 16 to 65) in the Netherlands Twin Register we constructed 19,543 pedigrees which specified all relations among nuclear family members and larger families in the register (N = 50,690 individuals). Data were available on total weekly MET minutes spent on leisure time exercise, and on total weekly MET minutes spent on exercise activities in team-based, solitary, competitive, non-competitive, externally paced and internally paced exercise. We analyzed the data in the Mendel software package (Lange et al. in Bioinformatics 29(12):1568–1570, 2013) under multiple definitions of household sharing and used data from spouses of twins to test phenotypic assortment, social homogamy, and marital interaction as potential sources of spousal resemblance. Results confirmed the influence of genetic factors on the total volume of weekly exercise behavior throughout the life span. Broad sense heritability ranged from 34 to 41% (19–26% A, 12–21% D), and did not depend on the definition for household sharing. Engaging in team-based, competitive, externally paced activities (e.g., soccer) was ~ 13% more heritable than engaging in non-competitive, solitary activities (e.g., jogging). Having shared a household as siblings explained 4–8% of the variance in adult exercise behavior, whereas sharing a household by spouses yielded higher C estimates (20–24%), as it incorporates spousal resemblance. Spousal resemblance was explained by both social homogamy and marital interaction, with little evidence for phenotypic assortment. We conclude that both the amount of voluntary exercise behavior and the preference for specific classes of exercise activities in adults is explained by additive and non-additive genetic factors and unique environmental influences that include correlated exercise behavior of spouses.