3D-additive deposition of an antibacterial and osteogenic silicon nitride coating on orthopaedic titanium substrate
3D-additive deposition of an antibacterial and osteogenic silicon nitride coating on orthopaedic titanium substrate
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骨科钛基材上抗菌和成骨氮化硅涂层的 3D 增材沉积
DOI：
10.1016/j.jmbbm.2019.103557
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发表时间：
2020
影响因子：
3.9
通讯作者：
Pezzotti Giuseppe
中科院分区：
文献类型：
--
作者：
Zanocco Matteo;Boschetto Francesco;Zhu Wenliang;Marin Elia;McEntire Bryan J.;Bal B. Sonny;Adachi Tetsuya;Yamamoto Toshiro;Kanamura Narisato;Ohgitani Eriko;Yamamoto Kengo;Mazda Osam;Pezzotti Giuseppe
3D增材制造方法通过自动激光烧结程序在生物医学级商业纯钛（cp-Ti）基底上制备致密的Si 3 N4陶瓷涂层。Si_3N_4涂层的厚度从1微米到几十微米。根据均匀性和耐刮擦性的预测，本研究选择了涂层厚度t= 15 ± 5 μm。根据标准划痕试验（ASTM C1624-05），Si 3 N4涂层满足生物材料应用所需的20 N阈值。Si_3N_4涂层赋予cp-Ti基体体相Si_3N_4的抗菌和成骨性能。这两个属性是可比的散装Si 3 N4生物医学植入物先前所述的。将新开发的Si 3 N4涂层应用于市售钛合金髋臼杯，用于全髋关节置换术。应用基于荧光素酶基因转化的“发光”测试来可视化革兰氏阴性大肠杆菌Si 3 N4涂层和未涂层钛合金髋臼杯的定殖。结果表明，涂层技术赋予抵抗表皮葡萄球菌和大肠杆菌粘附到散装髋臼窝。
A 3D-additive manufacturing approach produced a dense Si3N4ceramic coating on a biomedical grade commercially pure titanium (cp-Ti) substrate by an automatic laser-sintering procedure. Si3N4coatings could be prepared with thicknesses from the single to the tens of microns. A coating thickness,t= 15 ± 5 μm, was selected for this study, based on projections of homogeneity and scratching resistance. The Si3N4coating met the 20 N threshold required for biomaterial applications, according to the standard scratch testing (ASTM C1624-05). The Si3N4coating imparted both the antibacterial and osteogenic properties of bulk Si3N4to the cp-Ti substrate. Both properties were comparable to those previously described for bulk Si3N4biomedical implants. The newly developed Si3N4-coating was applied to commercially available Ti-alloy acetabular shells for total hip arthroplasty. A “glowing” test based on luciferase gene transformation was applied to visualize the colonization of gram-negativeEscherichia colion Si3N4-coated and uncoated Ti-alloy acetabular shells. The results showed that the coating technology conferred resistance toStaphylococcus epidermidisandEscherichia coliadhesion onto the bulk acetabular sockets.