The Association of Axial Length with Macular Microvascular Changes in Chinese Diabetic Retinopathy Patients.
The Association of Axial Length with Macular Microvascular Changes in Chinese Diabetic Retinopathy Patients.
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DOI：
10.2147/ijgm.s364790
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发表时间：
2022
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
--
作者：
目的应用光学相干断层扫描血管造影（OCTA）比较不同眼轴长度（AL）的非增殖性糖尿病视网膜病变（NPDR）患者黄斑区血流密度、中心凹下脉络膜厚度（SFCT）和视网膜外层厚度（ORT）的差异。将42例不同眼轴的NPDR患者分为3组：A组：22 mm≤AL<24 mm; B组：24 mm≤AL<26 mm; C组：AL≥26 mm，分别对黄斑区的表浅毛细血管丛（SCP）、黄斑中心凹区、黄斑旁区、黄斑中心凹周围区及整个黄斑区的血管长度密度（VLD）和血管灌注密度（VPD）进行分析。分析眼轴长度、黄斑微血管密度、SFCT和视网膜外厚度（ORT）之间的相关性。与A、B组相比，C组除中心凹区外，VLD、VPD均显著降低，且VLD、VPD与AL呈负相关; A、B、C组间SFCT差异显著，且SFCT与AL呈负相关;与A组相比，C组龈旁ORT显著低于A组，中央凹旁ORT与AL呈负相关，在不同AL的NPDR患者中，随着AL的增加，黄斑微血管密度、SFCT和中央凹旁ORT均下降。
To use optical coherence tomography angiography (OCTA) to compare macular blood flow density, subfoveal choroidal thickness (SFCT) and outer retina thickness (ORT) in non-proliferative diabetic retinopathy (NPDR) patients with different axial length (AL). Total 42 patients with NPDR with different eye axis were divided into three groups: group A: 22 mm≤AL<24 mm; group B: 24 mm≤AL<26 mm; group C: AL≥26 mm. Superficial capillary plexus (SCP) in the macular area, vascular length density (VLD) and vascular perfusion density (VPD) in the foveal region, the parafoveal region, the perifoveal region and whole macular region were analyzed. The correlations among axial length, macular microvascular density, SFCT and outer retinal thickness (ORT) were analyzed. Compared with group A and B, VLD and VPD in group C were significantly lower except the foveal region, and VLD and VPD were negatively correlated with AL. The difference in SFCT among group A, B and C was significant, and SFCT was negatively correlated with AL. Compared with group A, parafoveal ORT in group C was significantly lower than that in group A, and parafoveal ORT was negatively correlated with AL. In NPDR patients with different AL, macular microvascular density, SFCT, and parafoveal ORT decreased with the increase of AL.