Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.

Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
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DOI:
10.1016/j.chom.2014.01.004
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发表时间:
2014-02-12
影响因子:
30.3
通讯作者:
Sher A
Sher A
中科院分区:
医学1区
文献类型:
--
作者:
Gazzinelli RT;Mendonça-Neto R;Lilue J;Howard J;Sher A

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Recent studies have revealed remarkable species specificity of the Toll-Like Receptors (TLR) 11 and TLR12, and the Immunity Related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed.
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