Development of invariant natural killer T cells.
Development of invariant natural killer T cells.
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DOI：
10.1016/j.coi.2016.01.001
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发表时间：
2016-04
影响因子：
7
通讯作者：
Gapin L
中科院分区：
文献类型：
--
作者：
Gapin L
不变的自然杀伤T（iNKT）细胞发育成功能不同的亚群。每个亚群表达在激活时调节细胞因子基因转录的转录因子的独特组合。组织内的组织分布和定位也在子集之间变化。重要的是，各种亚群的相对丰度直接导致几个免疫学参数的改变，这些参数随后影响免疫应答。在这里，我回顾了我们对iNKT细胞亚群发育的分子调控的理解的最新进展。
Invariant natural killer T (iNKT) cells develop into functionally distinct subsets. Each subset expresses a unique combination of transcription factors that regulate cytokine gene transcription upon activation. The tissue distribution and localization within tissues also varies between subsets. Importantly, the relative abundance of the various subsets is directly responsible for altering several immunological parameters, which subsequently affect the immune response. Here, I review recent advances in our understanding of the molecular regulation of iNKT cell subset development.